DegronMD

Uniprot ID: O60716

Source protein: Catenin delta-1

Source gene: CTNND1

Class: DEG_APCC_DBOX_1

Location: 343:351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9859

ASA_SCORE: 74.3667

COIL: 0.5293

CONS_SCORE: 0.4824

DSS_SCORE: 0.4873

HELIX: 0.3998

FCONS_SCORE: 1.2097

RIG_SCORE: 0.6871

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R354H	TCGA-B5-A0JY	UCEC	TCGA	ERGSLASLD	DEG_APCC_DBOX_1	0.25
p.P338S	TCGA-W5-AA39	CHOL	TCGA	ERGSLASLD	DEG_APCC_DBOX_1	0.1944
p.W336R	TCGA-YL-A9WY	PRAD	TCGA	ERGSLASLD	DEG_APCC_DBOX_1	0.1389
p.R360Q	DO1285	BRCA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.0833
p.R360Q	DO219771	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.0833
p.R360Q	DO43907	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.0833
p.R360Q	DO43971	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.0833
p.R357P	DO234287	ESAD	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.1667
p.Q340H	DO228905	LICA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.25
p.Q340H	DO228974	LICA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.25
p.A345S	DO229027	LICA	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.7588
p.V352L	DO25471	LUAD	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.75
p.R338H	DO223287	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.1944
p.K347Q	DO43041	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.6944
p.N348S	DO41235	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.7069
p.C349W	DO42673	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.7
p.R357Q	DO42665	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.1667
p.K343T	DO43971	UCEC	ICGC	ERGSLASLD	DEG_APCC_DBOX_1	0.7306
p.R344Q	SIDM00893	Breast Carcinoma	GDSC	ERGSLASLD	DEG_APCC_DBOX_1	0.7329
p.R344Q	ACH-000536	Breast Cancer	CCLE	ERGSLASLD	DEG_APCC_DBOX_1	0.7329
p.R344Q	BT-20	breast	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	0.7329
p.P361T	SIDM00877	Breast Carcinoma	GDSC	ERGSLASLD	DEG_APCC_DBOX_1	0.0556
p.P361T	ACH-000196	Breast Cancer	CCLE	ERGSLASLD	DEG_APCC_DBOX_1	0.0556
p.P361T	HCC1599	breast	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	0.0556
p.Y334H	SIDM01608	Endometrial Carcinoma	GDSC	ERGSLASLD	DEG_APCC_DBOX_1	0.5278
p.Y334H	ACH-000990	Endometrial/Uterine Cancer	CCLE	ERGSLASLD	DEG_APCC_DBOX_1	0.5278
p.T348S	LOXIMVI	skin	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	0.7116
p.R342C	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERGSLASLD	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERGSLASLD

Degron related mutations and impact score

Drug responses associated with CTNND1 mutations

All proteins holding degron of ERGSLASLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60716	Catenin delta-1	DEG_APCC_DBOX_1	343:351	ERGSLASLD	APC,CDC20,FZR1	0.9859	More...