DegronMD

Uniprot ID: P10075

Source protein: Zinc finger protein GLI4

Source gene: GLI4

Class: DEG_COP1_1

Location: 6:16

E3 ligase: COP1

DEGRON score: 0.737

ASA_SCORE: 97.0455

COIL: 0.9576

CONS_SCORE: 0.6894

DSS_SCORE: 0.7692

HELIX: 0.0193

FCONS_SCORE: 0.7795

RIG_SCORE: 0.6081

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P14L	TCGA-21-1080	LUSC	TCGA	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	TCGA-A6-6654	COAD	TCGA	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	TCGA-D9-A149	SKCM	TCGA	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	DO9498	COAD	ICGC	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	DO26502	LUSC	ICGC	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	DO37420	SKCM	ICGC	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	SIDM00594	Acute Myeloid Leukemia	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P14L	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	DIQESPSVPSP	DEG_COP1_1	0.7582
p.P22L	TCGA-5M-AAT6	COAD	TCGA	DIQESPSVPSP	DEG_COP1_1	0.1667
p.P22L	DO223703	COAD	ICGC	DIQESPSVPSP	DEG_COP1_1	0.1667
p.P11H	TCGA-AJ-A3EK	UCEC	TCGA	DIQESPSVPSP	DEG_COP1_1	0.6583
p.P11H	DO41584	UCEC	ICGC	DIQESPSVPSP	DEG_COP1_1	0.6583
p.G5W	TCGA-AX-A1C4	UCEC	TCGA	DIQESPSVPSP	DEG_COP1_1	0.3056
p.G5W	DO42480	UCEC	ICGC	DIQESPSVPSP	DEG_COP1_1	0.3056
p.S21A	TCGA-CA-6717	COAD	TCGA	DIQESPSVPSP	DEG_COP1_1	0.1944
p.S21A	DO8264	COAD	ICGC	DIQESPSVPSP	DEG_COP1_1	0.1944
p.V17F	TCGA-CC-A7IH	LIHC	TCGA	DIQESPSVPSP	DEG_COP1_1	0.3056
p.V17F	DO228976	LICA	ICGC	DIQESPSVPSP	DEG_COP1_1	0.3056
p.V17F	DO52181	LIHC	ICGC	DIQESPSVPSP	DEG_COP1_1	0.3056
p.G5R	TCGA-W3-A824	SKCM	TCGA	DIQESPSVPSP	DEG_COP1_1	0.3056
p.G5R	DO51271	SKCM	ICGC	DIQESPSVPSP	DEG_COP1_1	0.3056
p.P14Q	SIDM02021	Esophageal Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7035
p.S15F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM01265	Plasma Cell Myeloma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM00844	Burkitt's Lymphoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM01187	Breast Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM00068	Colorectal Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982
p.S15F	SIDM00257	Neuroblastoma	GDSC	DIQESPSVPSP	DEG_COP1_1	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DIQESPSVPSP

Degron related mutations and impact score

Drug responses associated with GLI4 mutations

All proteins holding degron of DIQESPSVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10075	Zinc finger protein GLI4	DEG_COP1_1	6:16	DIQESPSVPSP	COP1	0.737	More...