DegronMD - P10075(GLI4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P14L	TCGA-21-1080	LUSC	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	TCGA-A6-6654	COAD	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	TCGA-D9-A149	SKCM	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	DO9498	COAD	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	DO26502	LUSC	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	DO37420	SKCM	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	SIDM00594	Acute Myeloid Leukemia	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	HEL	haematopoietic and lymphoid tissue	COSMIC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P14L	CMK	haematopoietic and lymphoid tissue	COSMIC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7582
p.P22L	TCGA-5M-AAT6	COAD	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.1667
p.P22L	DO223703	COAD	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.1667
p.P11H	TCGA-AJ-A3EK	UCEC	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.6583
p.P11H	DO41584	UCEC	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.6583
p.G5W	TCGA-AX-A1C4	UCEC	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.3056
p.G5W	DO42480	UCEC	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.3056
p.S21A	TCGA-CA-6717	COAD	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.1944
p.S21A	DO8264	COAD	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.1944
p.V17F	TCGA-CC-A7IH	LIHC	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.3056
p.V17F	DO228976	LICA	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.3056
p.V17F	DO52181	LIHC	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.3056
p.G5R	TCGA-W3-A824	SKCM	TCGA	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.3056
p.G5R	DO51271	SKCM	ICGC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation rewiring degron network	0.3056
p.D105H	DO227947	BRCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7688
p.R92H	DO227842	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.V97L	DO229010	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.V97L	DO229013	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.V97L	DO229016	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.V97L	DO229003	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.V97L	DO229005	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.R105S	DO223025	ESCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6316
p.Q103L	DO26993	LUSC	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7765
p.L100R	DO27334	LUSC	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7316
p.V97E	DO229470	SKCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.25
p.A96V	DO229259	THCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.2222
p.C113F	DO229216	THCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1944
p.P14Q	SIDM02021	Esophageal Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7035
p.S15F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM01265	Plasma Cell Myeloma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM00844	Burkitt's Lymphoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM01187	Breast Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM00068	Colorectal Carcinoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM00431	T-Lymphoblastic Leukemia	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.S15F	SIDM00257	Neuroblastoma	GDSC	DIQESPSVPSP	DEG_COP1_1	6:16	Mutation altering degron motif	0.7982
p.L107I	SIDM00200	Ewing's Sarcoma	GDSC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.6063
p.R109L	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.R109L	ACH-000785	Lung Cancer	CCLE	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.3056
p.G95E	ACH-000730	Skin Cancer	CCLE	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1944
p.R92C	OSC-20	upper aerodigestive tract	COSMIC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation rewiring degron network	0.1111
p.P102L	SK-MEL-2	skin	COSMIC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7582
p.N108S	GP5d	large intestine	COSMIC	LRSLLRSLP	DEG_APCC_DBOX_1	100:108	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLI4

UniProt ID: P10075

Entrez ID: 2738

Protein name: Zinc finger protein GLI4 (Krueppel-related zinc finger protein 4) (Protein HKR4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLI4 in