DegronMD

Uniprot ID: P10075

Source protein: Zinc finger protein GLI4

Source gene: GLI4

Class: DEG_APCC_DBOX_1

Location: 100:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9335

ASA_SCORE: 95.6444

COIL: 0.7029

CONS_SCORE: 0.7235

DSS_SCORE: 0.5755

HELIX: 0.2531

FCONS_SCORE: 1.2174

RIG_SCORE: 0.7214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D105H	DO227947	BRCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.7688
p.R92H	DO227842	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.1111
p.V97L	DO229010	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.25
p.V97L	DO229013	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.25
p.V97L	DO229016	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.25
p.V97L	DO229003	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.25
p.V97L	DO229005	COCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.25
p.R105S	DO223025	ESCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.6316
p.Q103L	DO26993	LUSC	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.7765
p.L100R	DO27334	LUSC	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.7316
p.V97E	DO229470	SKCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.25
p.A96V	DO229259	THCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.2222
p.C113F	DO229216	THCA	ICGC	LRSLLRSLP	DEG_APCC_DBOX_1	0.1944
p.L107I	SIDM00200	Ewing's Sarcoma	GDSC	LRSLLRSLP	DEG_APCC_DBOX_1	0.6063
p.R109L	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LRSLLRSLP	DEG_APCC_DBOX_1	0.3056
p.R109L	ACH-000785	Lung Cancer	CCLE	LRSLLRSLP	DEG_APCC_DBOX_1	0.3056
p.G95E	ACH-000730	Skin Cancer	CCLE	LRSLLRSLP	DEG_APCC_DBOX_1	0.1944
p.R92C	OSC-20	upper_aerodigestive_tract	COSMIC	LRSLLRSLP	DEG_APCC_DBOX_1	0.1111
p.P102L	SK-MEL-2	skin	COSMIC	LRSLLRSLP	DEG_APCC_DBOX_1	0.7582
p.N108S	GP5d	large_intestine	COSMIC	LRSLLRSLP	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10075	Zinc finger protein GLI4	DEG_APCC_DBOX_1	100:108	LRSLLRSLP	APC,CDC20,FZR1	0.9335	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons