DegronMD

Uniprot ID: P33151

Source protein: Cadherin-5

Source gene: CDH5

Class: DEG_Kelch_Keap1_1

Location: 124:129

E3 ligase: KEAP1

DEGRON score: 0.9486

ASA_SCORE: 79.1

COIL: 0.8425

CONS_SCORE: 0.4798

DSS_SCORE: 0.3365

HELIX: 0.0128

FCONS_SCORE: 0.8096

RIG_SCORE: 0.7742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L118I	TCGA-A5-A0G2	UCEC	TCGA	DKDTGE	DEG_Kelch_Keap1_1	0.1667
p.L118I	DO41235	UCEC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.1667
p.H117N	TCGA-EE-A20F	SKCM	TCGA	DKDTGE	DEG_Kelch_Keap1_1	0.1389
p.H117N	DO37961	SKCM	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.1389
p.D126G	TCGA-EO-A22R	UCEC	TCGA	DKDTGE	DEG_Kelch_Keap1_1	0.7198
p.D126G	DO42713	UCEC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.7198
p.P134H	TCGA-EO-A22U	UCEC	TCGA	DKDTGE	DEG_Kelch_Keap1_1	0.1944
p.P134H	DO43755	UCEC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.1944
p.G128C	TCGA-ER-A19B	SKCM	TCGA	DKDTGE	DEG_Kelch_Keap1_1	0.76
p.G128C	DO47491	SKCM	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.76
p.P134L	TCGA-XF-A9T0	BLCA	TCGA	DKDTGE	DEG_Kelch_Keap1_1	0.1944
p.P134L	DO51920	BLCA	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.1944
p.A134S	DO228974	LICA	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.1944
p.S114L	DO23360	LINC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.0556
p.P115H	DO23907	LUAD	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.0833
p.P131S	DO33084	PACA	ICGC	DKDTGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33151	Cadherin-5	DEG_Kelch_Keap1_1	124:129	DKDTGE	KEAP1	0.9486	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons