DegronMD - P33151(CDH5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V421A	TCGA-43-A56U	LUSC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.25
p.V421A	DO49083	LUSC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.25
p.L118I	TCGA-A5-A0G2	UCEC	TCGA	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1667
p.L118I	DO41235	UCEC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1667
p.K415N	TCGA-AP-A0LE	UCEC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation substituting flanking lysine	0.1944
p.K415N	DO43418	UCEC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation substituting flanking lysine	0.1944
p.E430V	TCGA-B0-5080	KIRC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7693
p.E430V	DO18154	KIRC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.7693
p.P439L	TCGA-CN-4741	HNSC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.0833
p.P439L	DO14313	HNSC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.0833
p.G416S	TCGA-EB-A41A	SKCM	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.G416S	TCGA-FI-A2D0	UCEC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.G416S	DO37429	SKCM	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.G416S	DO43891	UCEC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1111
p.H117N	TCGA-EE-A20F	SKCM	TCGA	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1389
p.H117N	DO37961	SKCM	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1389
p.D126G	TCGA-EO-A22R	UCEC	TCGA	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation altering degron motif	0.7198
p.D126G	DO42713	UCEC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation altering degron motif	0.7198
p.P134H	TCGA-EO-A22U	UCEC	TCGA	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1944
p.P134H	DO43755	UCEC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1944
p.G128C	TCGA-ER-A19B	SKCM	TCGA	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation altering degron motif	0.76
p.G128C	DO47491	SKCM	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation altering degron motif	0.76
p.F418L	TCGA-IB-7651	PAAD	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1667
p.F418L	DO46657	PAAD	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1667
p.E430D	TCGA-MA-AA3Z	CESC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.5647
p.E430D	DO219722	CESC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.5647
p.E430D	SIDM00253	Neuroblastoma	GDSC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.5647
p.E430D	ACH-002284	Neuroblastoma	CCLE	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.5647
p.E430D	NB6	autonomic ganglia	COSMIC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.5647
p.P134L	TCGA-XF-A9T0	BLCA	TCGA	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1944
p.P134L	DO51920	BLCA	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1944
p.F418S	DO233668	GACA	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1667
p.A134S	DO228974	LICA	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.1944
p.D414Y	DO229018	LICA	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.0556
p.S114L	DO23360	LINC	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.0556
p.P115H	DO23907	LUAD	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.0833
p.D426N	DO220907	MELA	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.5821
p.P131S	DO33084	PACA	ICGC	DKDTGE	DEG_Kelch_Keap1_1	124:129	Mutation rewiring degron network	0.2778
p.K415E	SIDM01617	Endometrial Carcinoma	GDSC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation substituting flanking lysine	0.1944
p.K424R	SIDM01770	Gastric Carcinoma	GDSC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation altering degron motif	0.6126
p.N417D	RKO	large intestine	COSMIC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	424:430	Mutation rewiring degron network	0.1389

Kaplan plot for CDH5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDH5

UniProt ID: P33151

Entrez ID: 1003

Protein name: Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDH5 in