DegronMD

Uniprot ID: P33151

Source protein: Cadherin-5

Source gene: CDH5

Class: LIG_APCC_ABBAyCdc20_2

Location: 424:430

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5168

ASA_SCORE: 58.2286

COIL: 0.4999

CONS_SCORE: 0.5292

DSS_SCORE: 0.2789

HELIX: 0.0076

FCONS_SCORE: 1.0064

RIG_SCORE: 0.8143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V421A	TCGA-43-A56U	LUSC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.25
p.V421A	DO49083	LUSC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.25
p.K415N	TCGA-AP-A0LE	UCEC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K415N	DO43418	UCEC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E430V	TCGA-B0-5080	KIRC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.7693
p.E430V	DO18154	KIRC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.7693
p.P439L	TCGA-CN-4741	HNSC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P439L	DO14313	HNSC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G416S	TCGA-EB-A41A	SKCM	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G416S	TCGA-FI-A2D0	UCEC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G416S	DO37429	SKCM	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G416S	DO43891	UCEC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.F418L	TCGA-IB-7651	PAAD	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.F418L	DO46657	PAAD	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E430D	TCGA-MA-AA3Z	CESC	TCGA	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E430D	DO219722	CESC	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E430D	SIDM00253	Neuroblastoma	GDSC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E430D	ACH-002284	Neuroblastoma	CCLE	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E430D	NB6	autonomic_ganglia	COSMIC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.5647
p.F418S	DO233668	GACA	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D414Y	DO229018	LICA	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D426N	DO220907	MELA	ICGC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.5821
p.K415E	SIDM01617	Endometrial Carcinoma	GDSC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K424R	SIDM01770	Gastric Carcinoma	GDSC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.6126
p.N417D	RKO	large_intestine	COSMIC	KGDIYNE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33151	Cadherin-5	LIG_APCC_ABBAyCdc20_2	424:430	KGDIYNE	APC,CDC20,FZR1	0.5168	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KGDIYNE

Degron related mutations and impact score

Drug responses associated with CDH5 mutations

All proteins holding degron of KGDIYNE