DegronMD

Uniprot ID: Q14789

Source protein: Golgin subfamily B member 1

Source gene: GOLGB1

Class: DEG_APCC_KENBOX_2

Location: 1040:1044

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6489

ASA_SCORE: 113.8

COIL: 0.0598

CONS_SCORE: 0.4381

DSS_SCORE: 0.4626

HELIX: 0.944

FCONS_SCORE: 1.3514

RIG_SCORE: 0.7051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1038Q	TCGA-66-2785	LUSC	TCGA	DKENK	DEG_APCC_KENBOX_2	0.2778
p.E1038Q	TCGA-DS-A1OB	CESC	TCGA	DKENK	DEG_APCC_KENBOX_2	0.2778
p.L1034F	TCGA-D3-A51J	SKCM	TCGA	DKENK	DEG_APCC_KENBOX_2	0.1667
p.E1036Q	TCGA-ZF-AA53	BLCA	TCGA	DKENK	DEG_APCC_KENBOX_2	0.2222
p.E1031Q	DO219096	BLCA	ICGC	DKENK	DEG_APCC_KENBOX_2	0.0833
p.E1033Q	DO6323	CESC	ICGC	DKENK	DEG_APCC_KENBOX_2	0.1389
p.E1033Q	DO26520	LUSC	ICGC	DKENK	DEG_APCC_KENBOX_2	0.1389
p.E1048G	DO233823	GACA	ICGC	DKENK	DEG_APCC_KENBOX_2	0.2222
p.S1053Y	DO43907	UCEC	ICGC	DKENK	DEG_APCC_KENBOX_2	0.0833
p.D1045E	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	DKENK	DEG_APCC_KENBOX_2	0.3056
p.D1045E	SIDM01442	Glioma	GDSC	DKENK	DEG_APCC_KENBOX_2	0.3056
p.D1045E	PC-3_[JPC-3]	lung	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.3056
p.N1048Y	SIDM00861	Ovarian Carcinoma	GDSC	DKENK	DEG_APCC_KENBOX_2	0.2222
p.N1048Y	ACH-000906	Ovarian Cancer	CCLE	DKENK	DEG_APCC_KENBOX_2	0.2222
p.N1048Y	ES-2	ovary	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.2222
p.C1050Y	ACH-000023	Pancreatic Cancer	CCLE	DKENK	DEG_APCC_KENBOX_2	0.1667
p.N1043Y	ES-2	ovary	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.7059
p.I1047M	MFE-296	endometrium	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.25
p.D1034V	IPC-298	skin	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.1667
p.D1040E	PC-3_[JPC-3]	lung	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.5647
p.L1036V	NCI-H1944	lung	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.2222
p.D1034Y	KYSE-520	oesophagus	COSMIC	DKENK	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14789	Golgin subfamily B member 1	DEG_APCC_KENBOX_2	1040:1044	DKENK	APC,CDC20,FZR1	0.6489	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons