DegronMD - Q14789(GOLGB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q1805L	TCGA-50-5930	LUAD	TCGA	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.1944
p.E1038Q	TCGA-66-2785	LUSC	TCGA	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.E1038Q	TCGA-DS-A1OB	CESC	TCGA	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2778
p.R1813I	TCGA-B5-A11E	UCEC	TCGA	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation altering degron motif	0.8102
p.E1803K	TCGA-CV-A45O	HNSC	TCGA	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.1389
p.L1034F	TCGA-D3-A51J	SKCM	TCGA	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1667
p.M1810I	TCGA-DA-A1I0	SKCM	TCGA	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation altering degron motif	0.7618
p.T1812A	TCGA-DK-A6AW	BLCA	TCGA	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation altering degron motif	0.7139
p.C1816Y	TCGA-GD-A76B	BLCA	TCGA	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation altering degron motif	0.7087
p.E1036Q	TCGA-ZF-AA53	BLCA	TCGA	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2222
p.C1811Y	DO51886	BLCA	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation altering degron motif	0.5976
p.T1807A	DO48566	BLCA	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.25
p.E1031Q	DO219096	BLCA	ICGC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0833
p.E1033Q	DO6323	CESC	ICGC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1389
p.E1033Q	DO26520	LUSC	ICGC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1389
p.E1048G	DO233823	GACA	ICGC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2222
p.N1822K	DO229025	LICA	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.2222
p.S1806R	DO229045	LICA	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.2222
p.P1816Q	DO229009	LICA	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation altering degron motif	0.7035
p.Q1800L	DO25189	LUAD	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.0556
p.R1808I	DO232224	PBCA	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.2778
p.R1808I	DO41644	UCEC	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.2778
p.M1805I	DO37719	SKCM	ICGC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.1944
p.S1053Y	DO43907	UCEC	ICGC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.0833
p.A1823V	SIDM00660	Colorectal Carcinoma	GDSC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.1944
p.A1823V	ACH-000985	Colon/Colorectal Cancer	CCLE	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.1944
p.A1823V	LS-411N	large intestine	COSMIC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation rewiring degron network	0.1944
p.D1045E	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.3056
p.D1045E	SIDM01442	Glioma	GDSC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.3056
p.D1045E	PC-3_[JPC-3]	lung	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.3056
p.N1048Y	SIDM00861	Ovarian Carcinoma	GDSC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2222
p.N1048Y	ACH-000906	Ovarian Cancer	CCLE	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2222
p.N1048Y	ES-2	ovary	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2222
p.C1050Y	ACH-000023	Pancreatic Cancer	CCLE	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1667
p.N1043Y	ES-2	ovary	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.7059
p.I1047M	MFE-296	endometrium	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.25
p.D1034V	IPC-298	skin	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1667
p.D1040E	PC-3_[JPC-3]	lung	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation altering degron motif	0.5647
p.A1818V	LS-411N	large intestine	COSMIC	TCSESVPSA	DEG_COP1_1	1810:1818	Mutation altering degron motif	0.5825
p.L1036V	NCI-H1944	lung	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.2222
p.D1034Y	KYSE-520	oesophagus	COSMIC	DKENK	DEG_APCC_KENBOX_2	1040:1044	Mutation rewiring degron network	0.1667

Kaplan plot for GOLGB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GOLGB1

UniProt ID: Q14789

Entrez ID: 2804

Protein name: Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GOLGB1 in