DegronMD

Uniprot ID: Q14789

Source protein: Golgin subfamily B member 1

Source gene: GOLGB1

Class: DEG_COP1_1

Location: 1810:1818

E3 ligase: COP1

DEGRON score: 0.7515

ASA_SCORE: 90.3667

COIL: 0.7281

CONS_SCORE: 0.3606

DSS_SCORE: 0.6239

HELIX: 0.257

FCONS_SCORE: 1.0191

RIG_SCORE: 0.6364

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1805L	TCGA-50-5930	LUAD	TCGA	TCSESVPSA	DEG_COP1_1	0.1944
p.R1813I	TCGA-B5-A11E	UCEC	TCGA	TCSESVPSA	DEG_COP1_1	0.8102
p.E1803K	TCGA-CV-A45O	HNSC	TCGA	TCSESVPSA	DEG_COP1_1	0.1389
p.M1810I	TCGA-DA-A1I0	SKCM	TCGA	TCSESVPSA	DEG_COP1_1	0.7618
p.T1812A	TCGA-DK-A6AW	BLCA	TCGA	TCSESVPSA	DEG_COP1_1	0.7139
p.C1816Y	TCGA-GD-A76B	BLCA	TCGA	TCSESVPSA	DEG_COP1_1	0.7087
p.C1811Y	DO51886	BLCA	ICGC	TCSESVPSA	DEG_COP1_1	0.5976
p.T1807A	DO48566	BLCA	ICGC	TCSESVPSA	DEG_COP1_1	0.25
p.N1822K	DO229025	LICA	ICGC	TCSESVPSA	DEG_COP1_1	0.2222
p.S1806R	DO229045	LICA	ICGC	TCSESVPSA	DEG_COP1_1	0.2222
p.P1816Q	DO229009	LICA	ICGC	TCSESVPSA	DEG_COP1_1	0.7035
p.Q1800L	DO25189	LUAD	ICGC	TCSESVPSA	DEG_COP1_1	0.0556
p.R1808I	DO232224	PBCA	ICGC	TCSESVPSA	DEG_COP1_1	0.2778
p.R1808I	DO41644	UCEC	ICGC	TCSESVPSA	DEG_COP1_1	0.2778
p.M1805I	DO37719	SKCM	ICGC	TCSESVPSA	DEG_COP1_1	0.1944
p.A1823V	SIDM00660	Colorectal Carcinoma	GDSC	TCSESVPSA	DEG_COP1_1	0.1944
p.A1823V	ACH-000985	Colon/Colorectal Cancer	CCLE	TCSESVPSA	DEG_COP1_1	0.1944
p.A1823V	LS-411N	large_intestine	COSMIC	TCSESVPSA	DEG_COP1_1	0.1944
p.A1818V	LS-411N	large_intestine	COSMIC	TCSESVPSA	DEG_COP1_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14789	Golgin subfamily B member 1	DEG_COP1_1	1810:1818	TCSESVPSA	COP1	0.7515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons