DegronMD

Uniprot ID: O60469

Source protein: Down syndrome cell adhesion molecule

Source gene: DSCAM

Class: CBL_PTK

Location: 1780:1790

E3 ligase: CBL

DEGRON score: 0.9509

ASA_SCORE: 86.7182

COIL: 0.873

CONS_SCORE: 0.3574

DSS_SCORE: 0.6381

HELIX: 0.0574

FCONS_SCORE: 1.1318

RIG_SCORE: 0.6435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1800R	TCGA-43-6770	LUSC	TCGA	DKESDSYSVSP	CBL_PTK	0.0556
p.S1800R	DO27644	LUSC	ICGC	DKESDSYSVSP	CBL_PTK	0.0556
p.S1787R	TCGA-56-7822	LUSC	TCGA	DKESDSYSVSP	CBL_PTK	0.7427
p.S1787R	DO26638	LUSC	ICGC	DKESDSYSVSP	CBL_PTK	0.7427
p.P1773L	TCGA-B5-A3FA	UCEC	TCGA	DKESDSYSVSP	CBL_PTK	0.1389
p.P1773L	DO52402	UCEC	ICGC	DKESDSYSVSP	CBL_PTK	0.1389
p.E1782D	TCGA-DK-AA77	BLCA	TCGA	DKESDSYSVSP	CBL_PTK	0.5647
p.E1782D	DO219014	BLCA	ICGC	DKESDSYSVSP	CBL_PTK	0.5647
p.V1788I	TCGA-DX-A6YQ	SARC	TCGA	DKESDSYSVSP	CBL_PTK	0.5965
p.V1788I	DO220002	SARC	ICGC	DKESDSYSVSP	CBL_PTK	0.5965
p.D1795N	TCGA-W3-A825	SKCM	TCGA	DKESDSYSVSP	CBL_PTK	0.1944
p.D1795N	DO51272	SKCM	ICGC	DKESDSYSVSP	CBL_PTK	0.1944
p.A1775V	TCGA-WE-AAA0	SKCM	TCGA	DKESDSYSVSP	CBL_PTK	0.1944
p.A1775V	DO51294	SKCM	ICGC	DKESDSYSVSP	CBL_PTK	0.1944
p.D1784N	DO222817	BTCA	ICGC	DKESDSYSVSP	CBL_PTK	0.5821
p.Q1792K	DO229028	LICA	ICGC	DKESDSYSVSP	CBL_PTK	0.2778
p.T1772K	DO229025	LICA	ICGC	DKESDSYSVSP	CBL_PTK	0.1111
p.A1776E	DO229038	LICA	ICGC	DKESDSYSVSP	CBL_PTK	0.2222
p.G1777E	DO229446	SKCA	ICGC	DKESDSYSVSP	CBL_PTK	0.25
p.S1787G	DO229259	THCA	ICGC	DKESDSYSVSP	CBL_PTK	0.6993
p.R1774G	DO229218	THCA	ICGC	DKESDSYSVSP	CBL_PTK	0.1667
p.D1780N	ACH-001515	Cervical Cancer	CCLE	DKESDSYSVSP	CBL_PTK	0.5821
p.M1783I	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	DKESDSYSVSP	CBL_PTK	0.7618
p.A1786T	SNU-1040	large_intestine	COSMIC	DKESDSYSVSP	CBL_PTK	0.7139
p.S1787F	SW982	soft_tissue	COSMIC	DKESDSYSVSP	CBL_PTK	0.7982
p.T1776M	TE-441-T	soft_tissue	COSMIC	DKESDSYSVSP	CBL_PTK	0.2222
p.E1784K	CP66-MEL	skin	COSMIC	DKESDSYSVSP	CBL_PTK	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60469	Down syndrome cell adhesion molecule	CBL_PTK	1780:1790	DKESDSYSVSP	CBL	0.9509	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons