DegronMD - O60469(DSCAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1071C	TCGA-22-1002	LUSC	TCGA	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.0556
p.G1071C	DO26429	LUSC	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.0556
p.K431Q	TCGA-28-1757	GBM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.5833
p.K431Q	DO12166	GBM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.5833
p.S1800R	TCGA-43-6770	LUSC	TCGA	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.0556
p.S1800R	DO27644	LUSC	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.0556
p.S1787R	TCGA-56-7822	LUSC	TCGA	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.7427
p.S1787R	DO26638	LUSC	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.7427
p.L1668F	TCGA-77-7141	LUSC	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1389
p.L1668F	DO26450	LUSC	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1389
p.P446L	TCGA-A6-5657	COAD	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.0833
p.P446L	DO10459	COAD	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.0833
p.D1661N	TCGA-AA-3544	COAD	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	TCGA-AA-3977	COAD	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	TCGA-AG-3892	READ	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	TCGA-B5-A0K9	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	TCGA-D3-A8GI	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	TCGA-EE-A29R	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	DO9130	COAD	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	DO8730	COAD	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	DO222798	COCA	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	DO36394	READ	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	DO37448	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	DO50284	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.D1661N	DO42097	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6932
p.T1648A	TCGA-AP-A056	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1111
p.T1648A	DO43971	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1111
p.T1648M	TCGA-AP-A0LM	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1111
p.T1648M	DO43306	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1111
p.R1657Q	TCGA-AZ-4315	COAD	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	TCGA-DF-A2KU	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	TCGA-EO-A22R	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	TCGA-IH-A3EA	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	TCGA-WE-A8ZN	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	DO8842	COAD	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	DO37667	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	DO51285	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	DO223286	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.R1657Q	DO42713	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6218
p.P1773L	TCGA-B5-A3FA	UCEC	TCGA	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1389
p.P1773L	DO52402	UCEC	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1389
p.Q1077H	TCGA-BF-A1PZ	SKCM	TCGA	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.Q1077H	DO50279	SKCM	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.G432R	TCGA-BF-AAP4	SKCM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.6457
p.G432R	DO219468	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.6457
p.T439M	TCGA-CM-6171	COAD	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.2778
p.T439M	DO8151	COAD	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.2778
p.T433K	TCGA-CV-A460	HNSC	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7306
p.T433K	DO52065	HNSC	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7306
p.T433K	DO229028	LICA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7306
p.S1646L	TCGA-D3-A8GS	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.0556
p.S1646L	DO220882	MELA	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.0556
p.S1646L	DO51248	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.0556
p.P1088L	TCGA-DA-A1IA	SKCM	TCGA	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.7582
p.P1088L	DO38022	SKCM	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.7582
p.P434H	TCGA-DF-A2KV	UCEC	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7694
p.P434H	DO219771	UCEC	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7694
p.E1782D	TCGA-DK-AA77	BLCA	TCGA	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.5647
p.E1782D	DO219014	BLCA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.5647
p.V1788I	TCGA-DX-A6YQ	SARC	TCGA	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.5965
p.V1788I	DO220002	SARC	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.5965
p.W440C	TCGA-EE-A2MS	SKCM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.25
p.W440C	DO37567	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.25
p.L1084F	TCGA-EO-A22U	UCEC	TCGA	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.587
p.L1084F	DO43755	UCEC	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.587
p.D444N	TCGA-FS-A1ZZ	SKCM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.1389
p.D444N	DO37412	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.1389
p.T1655N	TCGA-NC-A5HR	LUSC	TCGA	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.3056
p.T1655N	DO229026	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.3056
p.T1655N	DO219203	LUSC	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.3056
p.D1795N	TCGA-W3-A825	SKCM	TCGA	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1944
p.D1795N	DO51272	SKCM	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1944
p.A1775V	TCGA-WE-AAA0	SKCM	TCGA	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1944
p.A1775V	DO51294	SKCM	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1944
p.D1784N	DO222817	BTCA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.5821
p.A421T	DO227549	COCA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.0833
p.T437M	DO234202	ESAD	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7423
p.Q1792K	DO229028	LICA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.2778
p.Q1096K	DO229022	LICA	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.1667
p.T1772K	DO229025	LICA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1111
p.P420T	DO229026	LICA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.0556
p.P1663T	DO229035	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.2778
p.P1663T	DO229037	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.2778
p.S1650R	DO229038	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1667
p.A1776E	DO229038	LICA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.2222
p.T1082N	DO229037	LICA	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.5944
p.V430M	DO229040	LICA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.6097
p.G1073R	DO50970	LICA	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.1111
p.P446S	DO222875	MELA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.0833
p.G1777E	DO229446	SKCA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.25
p.Y1090S	DO227681	SKCA	ICGC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.712
p.G432E	DO37782	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.6087
p.S1787G	DO229259	THCA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.6993
p.R1774G	DO229218	THCA	ICGC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.1667
p.T1083S	SIDM01033	Bladder Carcinoma	GDSC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.6005
p.T1083S	ACH-000486	Bladder Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.6005
p.T1083S	KU-19-19	urinary tract	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.6005
p.M1658V	SIDM01617	Endometrial Carcinoma	GDSC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6097
p.M1658V	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation altering degron motif	0.6097
p.E1671Q	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.0556
p.E1671Q	ACH-000912	Lung Cancer	CCLE	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.0556
p.A421V	ACH-000961	Endometrial/Uterine Cancer	CCLE	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.0833
p.E1093K	ACH-000974	Endometrial/Uterine Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.25
p.E1093K	ACH-002026	Endometrial/Uterine Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.25
p.D1780N	ACH-001515	Cervical Cancer	CCLE	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.5821
p.E1085D	ACH-001786	Colon/Colorectal Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.5647
p.E1078K	ACH-002396	Bone Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.25
p.E1078K	Sarc9371	bone	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.25
p.V1094I	RERF-LC-FM	lung	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.V1094I	CTB-1	haematopoietic and lymphoid tissue	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.Y1081C	SK-MEL-30	skin	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.7087
p.M1783I	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.7618
p.A1786T	SNU-1040	large intestine	COSMIC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.7139
p.D1077N	ME-1	haematopoietic and lymphoid tissue	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2222
p.E1654K	LS-1034	large intestine	COSMIC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.2778
p.E1654K	SW684	soft tissue	COSMIC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.2778
p.P431Q	KYSE-150	oesophagus	COSMIC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7035
p.P432S	VMRC-LCD	lung	COSMIC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.6752
p.S1787F	SW982	soft tissue	COSMIC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.7982
p.E1648K	Sarc9371	bone	COSMIC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1111
p.L1649M	K-562	haematopoietic and lymphoid tissue	COSMIC	LRMHID	LIG_APCC_ABBA_1	1656:1661	Mutation rewiring degron network	0.1389
p.Y1092C	EN	endometrium	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation rewiring degron network	0.2778
p.V426M	KM-H2	haematopoietic and lymphoid tissue	COSMIC	VKGTPLPT	DEG_SCF_FBW7_1	430:437	Mutation rewiring degron network	0.2222
p.T1776M	TE-441-T	soft tissue	COSMIC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation rewiring degron network	0.2222
p.R1082I	SNU-81	large intestine	COSMIC	TTTLEDVPSY	DEG_COP1_1	1081:1090	Mutation altering degron motif	0.8102
p.E1784K	CP66-MEL	skin	COSMIC	DKESDSYSVSP	CBL_PTK	1780:1790	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DSCAM

UniProt ID: O60469

Entrez ID: 1826

Protein name: Down syndrome cell adhesion molecule (CHD2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DSCAM in