DegronMD

Uniprot ID: O60469

Source protein: Down syndrome cell adhesion molecule

Source gene: DSCAM

Class: DEG_SCF_FBW7_1

Location: 430:437

E3 ligase: FBXW7

DEGRON score: 0.9259

ASA_SCORE: 65.55

COIL: 0.8071

CONS_SCORE: 0.3651

DSS_SCORE: 0.2734

HELIX: 0.0076

FCONS_SCORE: 0.9516

RIG_SCORE: 0.7702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K431Q	TCGA-28-1757	GBM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.5833
p.K431Q	DO12166	GBM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.5833
p.P446L	TCGA-A6-5657	COAD	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.0833
p.P446L	DO10459	COAD	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.0833
p.G432R	TCGA-BF-AAP4	SKCM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.6457
p.G432R	DO219468	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.6457
p.T439M	TCGA-CM-6171	COAD	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.2778
p.T439M	DO8151	COAD	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.2778
p.T433K	TCGA-CV-A460	HNSC	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.7306
p.T433K	DO52065	HNSC	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.7306
p.T433K	DO229028	LICA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.7306
p.P434H	TCGA-DF-A2KV	UCEC	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.7694
p.P434H	DO219771	UCEC	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.7694
p.W440C	TCGA-EE-A2MS	SKCM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.25
p.W440C	DO37567	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.25
p.D444N	TCGA-FS-A1ZZ	SKCM	TCGA	VKGTPLPT	DEG_SCF_FBW7_1	0.1389
p.D444N	DO37412	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.1389
p.A421T	DO227549	COCA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.0833
p.T437M	DO234202	ESAD	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.7423
p.P420T	DO229026	LICA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.0556
p.V430M	DO229040	LICA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.6097
p.P446S	DO222875	MELA	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.0833
p.G432E	DO37782	SKCM	ICGC	VKGTPLPT	DEG_SCF_FBW7_1	0.6087
p.A421V	ACH-000961	Endometrial/Uterine Cancer	CCLE	VKGTPLPT	DEG_SCF_FBW7_1	0.0833
p.P431Q	KYSE-150	oesophagus	COSMIC	VKGTPLPT	DEG_SCF_FBW7_1	0.7035
p.P432S	VMRC-LCD	lung	COSMIC	VKGTPLPT	DEG_SCF_FBW7_1	0.6752
p.V426M	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VKGTPLPT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60469	Down syndrome cell adhesion molecule	DEG_SCF_FBW7_1	430:437	VKGTPLPT	FBXW7	0.9259	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VKGTPLPT

Degron related mutations and impact score

Drug responses associated with DSCAM mutations

All proteins holding degron of VKGTPLPT