DegronMD

Uniprot ID: O60469

Source protein: Down syndrome cell adhesion molecule

Source gene: DSCAM

Class: LIG_APCC_ABBA_1

Location: 1656:1661

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9478

ASA_SCORE: 93.45

COIL: 0.7203

CONS_SCORE: 0.3397

DSS_SCORE: 0.4147

HELIX: 0.1217

FCONS_SCORE: 1.2179

RIG_SCORE: 0.8087

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1668F	TCGA-77-7141	LUSC	TCGA	LRMHID	LIG_APCC_ABBA_1	0.1389
p.L1668F	DO26450	LUSC	ICGC	LRMHID	LIG_APCC_ABBA_1	0.1389
p.D1661N	TCGA-AA-3544	COAD	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	TCGA-AA-3977	COAD	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	TCGA-AG-3892	READ	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	TCGA-B5-A0K9	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	TCGA-D3-A8GI	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	TCGA-EE-A29R	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	DO9130	COAD	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	DO8730	COAD	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	DO222798	COCA	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	DO36394	READ	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	DO37448	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	DO50284	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6932
p.D1661N	DO42097	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6932
p.T1648A	TCGA-AP-A056	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	0.1111
p.T1648A	DO43971	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	0.1111
p.T1648M	TCGA-AP-A0LM	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	0.1111
p.T1648M	DO43306	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	0.1111
p.R1657Q	TCGA-AZ-4315	COAD	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	TCGA-DF-A2KU	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	TCGA-EO-A22R	UCEC	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	TCGA-IH-A3EA	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	TCGA-WE-A8ZN	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	DO8842	COAD	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	DO37667	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	DO51285	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	DO223286	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6218
p.R1657Q	DO42713	UCEC	ICGC	LRMHID	LIG_APCC_ABBA_1	0.6218
p.S1646L	TCGA-D3-A8GS	SKCM	TCGA	LRMHID	LIG_APCC_ABBA_1	0.0556
p.S1646L	DO220882	MELA	ICGC	LRMHID	LIG_APCC_ABBA_1	0.0556
p.S1646L	DO51248	SKCM	ICGC	LRMHID	LIG_APCC_ABBA_1	0.0556
p.T1655N	TCGA-NC-A5HR	LUSC	TCGA	LRMHID	LIG_APCC_ABBA_1	0.3056
p.T1655N	DO229026	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	0.3056
p.T1655N	DO219203	LUSC	ICGC	LRMHID	LIG_APCC_ABBA_1	0.3056
p.P1663T	DO229035	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	0.2778
p.P1663T	DO229037	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	0.2778
p.S1650R	DO229038	LICA	ICGC	LRMHID	LIG_APCC_ABBA_1	0.1667
p.M1658V	SIDM01617	Endometrial Carcinoma	GDSC	LRMHID	LIG_APCC_ABBA_1	0.6097
p.M1658V	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRMHID	LIG_APCC_ABBA_1	0.6097
p.E1671Q	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LRMHID	LIG_APCC_ABBA_1	0.0556
p.E1671Q	ACH-000912	Lung Cancer	CCLE	LRMHID	LIG_APCC_ABBA_1	0.0556
p.E1654K	LS-1034	large_intestine	COSMIC	LRMHID	LIG_APCC_ABBA_1	0.2778
p.E1654K	SW684	soft_tissue	COSMIC	LRMHID	LIG_APCC_ABBA_1	0.2778
p.E1648K	Sarc9371	bone	COSMIC	LRMHID	LIG_APCC_ABBA_1	0.1111
p.L1649M	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	LRMHID	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRMHID

Degron related mutations and impact score

Drug responses associated with DSCAM mutations

All proteins holding degron of LRMHID

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60469	Down syndrome cell adhesion molecule	LIG_APCC_ABBA_1	1656:1661	LRMHID	APC,CDC20,FZR1	0.9478	More...