DegronMD

Uniprot ID: O60469

Source protein: Down syndrome cell adhesion molecule

Source gene: DSCAM

Class: DEG_COP1_1

Location: 1081:1090

E3 ligase: COP1

DEGRON score: 0.8809

ASA_SCORE: 65.25

COIL: 0.6849

CONS_SCORE: 0.5641

DSS_SCORE: 0.485

HELIX: 0.0099

FCONS_SCORE: 1.0907

RIG_SCORE: 0.7771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1071C	TCGA-22-1002	LUSC	TCGA	TTTLEDVPSY	DEG_COP1_1	0.0556
p.G1071C	DO26429	LUSC	ICGC	TTTLEDVPSY	DEG_COP1_1	0.0556
p.Q1077H	TCGA-BF-A1PZ	SKCM	TCGA	TTTLEDVPSY	DEG_COP1_1	0.2222
p.Q1077H	DO50279	SKCM	ICGC	TTTLEDVPSY	DEG_COP1_1	0.2222
p.P1088L	TCGA-DA-A1IA	SKCM	TCGA	TTTLEDVPSY	DEG_COP1_1	0.7582
p.P1088L	DO38022	SKCM	ICGC	TTTLEDVPSY	DEG_COP1_1	0.7582
p.L1084F	TCGA-EO-A22U	UCEC	TCGA	TTTLEDVPSY	DEG_COP1_1	0.587
p.L1084F	DO43755	UCEC	ICGC	TTTLEDVPSY	DEG_COP1_1	0.587
p.Q1096K	DO229022	LICA	ICGC	TTTLEDVPSY	DEG_COP1_1	0.1667
p.T1082N	DO229037	LICA	ICGC	TTTLEDVPSY	DEG_COP1_1	0.5944
p.G1073R	DO50970	LICA	ICGC	TTTLEDVPSY	DEG_COP1_1	0.1111
p.Y1090S	DO227681	SKCA	ICGC	TTTLEDVPSY	DEG_COP1_1	0.712
p.T1083S	SIDM01033	Bladder Carcinoma	GDSC	TTTLEDVPSY	DEG_COP1_1	0.6005
p.T1083S	ACH-000486	Bladder Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	0.6005
p.T1083S	KU-19-19	urinary_tract	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.6005
p.E1093K	ACH-000974	Endometrial/Uterine Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	0.25
p.E1093K	ACH-002026	Endometrial/Uterine Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	0.25
p.E1085D	ACH-001786	Colon/Colorectal Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	0.5647
p.E1078K	ACH-002396	Bone Cancer	CCLE	TTTLEDVPSY	DEG_COP1_1	0.25
p.E1078K	Sarc9371	bone	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.25
p.V1094I	RERF-LC-FM	lung	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.2222
p.V1094I	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.2222
p.Y1081C	SK-MEL-30	skin	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.7087
p.D1077N	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.2222
p.Y1092C	EN	endometrium	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.2778
p.R1082I	SNU-81	large_intestine	COSMIC	TTTLEDVPSY	DEG_COP1_1	0.8102

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60469	Down syndrome cell adhesion molecule	DEG_COP1_1	1081:1090	TTTLEDVPSY	COP1	0.8809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TTTLEDVPSY

Degron related mutations and impact score

Drug responses associated with DSCAM mutations

All proteins holding degron of TTTLEDVPSY