DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DKMGRKYTSTP
Uniprot ID:
Q5VU65
Source protein:
Nuclear pore membrane glycoprotein 210-like
Source gene:
NUP210L
Class:
CBL_PTK
Location:
1066:1076
E3 ligase:
CBL
DEGRON score:
0.9333
ASA_SCORE:
79.1909
COIL:
0.5226
CONS_SCORE:
0.3845
DSS_SCORE:
0.3638
HELIX:
0.0055
FCONS_SCORE:
0.7255
RIG_SCORE:
0.7421
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K1071T
TCGA-85-6560
LUSC
TCGA
DKMGRKYTSTP
CBL_PTK
0.6195
p.R1070I
TCGA-AG-A002
READ
TCGA
DKMGRKYTSTP
CBL_PTK
0.6991
p.P1084L
TCGA-BF-A3DJ
SKCM
TCGA
DKMGRKYTSTP
CBL_PTK
0.1111
p.R1070K
TCGA-CJ-4918
KIRC
TCGA
DKMGRKYTSTP
CBL_PTK
0.6126
p.R1077W
TCGA-CM-6172
COAD
TCGA
DKMGRKYTSTP
CBL_PTK
0.3056
p.Y1072H
SIDM01055
Glioblastoma
GDSC
DKMGRKYTSTP
CBL_PTK
0.834
p.Y1072H
ACH-000098
Brain Cancer
CCLE
DKMGRKYTSTP
CBL_PTK
0.834
p.Y1072H
GAMG
central_nervous_system
COSMIC
DKMGRKYTSTP
CBL_PTK
0.834
p.L1060R
SIDM00193
Colorectal Carcinoma
GDSC
DKMGRKYTSTP
CBL_PTK
0.1667
p.L1060R
ACH-000991
Colon/Colorectal Cancer
CCLE
DKMGRKYTSTP
CBL_PTK
0.1667
p.L1060R
SNU-81
large_intestine
COSMIC
DKMGRKYTSTP
CBL_PTK
0.1667
p.P1084S
ACH-001566
Skin Cancer
CCLE
DKMGRKYTSTP
CBL_PTK
0.1111
Drug responses associated with NUP210L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKMGRKYTSTP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VU65
Nuclear pore membrane glycoprotein 210-like
CBL_PTK
1066:1076
DKMGRKYTSTP
CBL
0.9333
More...
