DegronMD - Q5VU65(NUP210L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K1071T	TCGA-85-6560	LUSC	TCGA	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation altering degron motif	0.6195
p.R1070I	TCGA-AG-A002	READ	TCGA	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation altering degron motif	0.6991
p.N40K	TCGA-AP-A0LS	UCEC	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.0556
p.N40K	DO43178	UCEC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.0556
p.R20H	TCGA-AX-A2HA	UCEC	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.R20H	DO42504	UCEC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.P1084L	TCGA-BF-A3DJ	SKCM	TCGA	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation rewiring degron network	0.1111
p.R32C	TCGA-CD-A4MI	STAD	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.R32C	DO228123	EOPC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.R32C	DO47717	STAD	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.R32C	SIDM01394	Kidney Carcinoma	GDSC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.R1070K	TCGA-CJ-4918	KIRC	TCGA	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation altering degron motif	0.6126
p.R1077W	TCGA-CM-6172	COAD	TCGA	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation rewiring degron network	0.3056
p.L35M	TCGA-EE-A29E	SKCM	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1944
p.L35M	DO37831	SKCM	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1944
p.L21I	DO222884	COCA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.3056
p.R23C	DO233088	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.8301
p.R23C	DO233944	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.8301
p.R23C	DO228963	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.8301
p.L26M	DO233272	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.711
p.G12C	DO233944	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.0556
p.P29Q	DO20917	KIRP	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.7035
p.T34N	DO228900	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.T34N	DO229024	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.R23S	DO228985	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.7427
p.Q34K	DO229029	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2222
p.L15I	DO229028	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1389
p.V30I	DO50970	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.5965
p.M36V	DO45073	LINC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1667
p.G12V	DO23508	LIRI	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.0556
p.K24R	DO26042	LUAD	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.7237
p.G39A	DO27612	LUSC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.0833
p.P29S	DO229459	SKCA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation altering degron motif	0.6752
p.M32I	DO218856	SKCA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.P17L	DO51237	SKCM	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1944
p.R20C	SIDM01943	Colorectal Carcinoma	GDSC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.2778
p.Y1072H	SIDM01055	Glioblastoma	GDSC	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation altering degron motif	0.834
p.Y1072H	ACH-000098	Brain Cancer	CCLE	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation altering degron motif	0.834
p.Y1072H	GAMG	central nervous system	COSMIC	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation altering degron motif	0.834
p.L35R	SIDM01078	Small Cell Lung Carcinoma	GDSC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1944
p.L35R	ACH-000790	Lung Cancer	CCLE	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1944
p.L35R	SHP-77	lung	COSMIC	HRLLLLFLV	DEG_APCC_DBOX_1	22:30	Mutation rewiring degron network	0.1944
p.L1060R	SIDM00193	Colorectal Carcinoma	GDSC	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation rewiring degron network	0.1667
p.L1060R	ACH-000991	Colon/Colorectal Cancer	CCLE	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation rewiring degron network	0.1667
p.L1060R	SNU-81	large intestine	COSMIC	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation rewiring degron network	0.1667
p.P1084S	ACH-001566	Skin Cancer	CCLE	DKMGRKYTSTP	CBL_PTK	1066:1076	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUP210L

UniProt ID: Q5VU65

Entrez ID: 91181

Protein name: Nuclear pore membrane glycoprotein 210-like (Nucleoporin 210 kDa-like) (Nucleoporin Nup210-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUP210L in