DegronMD

Uniprot ID: Q5VU65

Source protein: Nuclear pore membrane glycoprotein 210-like

Source gene: NUP210L

Class: DEG_APCC_DBOX_1

Location: 22:30

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7105

ASA_SCORE: 71.4

COIL: 0.0723

CONS_SCORE: 0.3655

DSS_SCORE: 0.0004

HELIX: 0.9222

FCONS_SCORE: 1.2716

RIG_SCORE: 1.0417

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N40K	TCGA-AP-A0LS	UCEC	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	0.0556
p.N40K	DO43178	UCEC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.0556
p.R20H	TCGA-AX-A2HA	UCEC	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.R20H	DO42504	UCEC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.R32C	TCGA-CD-A4MI	STAD	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.R32C	DO228123	EOPC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.R32C	DO47717	STAD	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.R32C	SIDM01394	Kidney Carcinoma	GDSC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.L35M	TCGA-EE-A29E	SKCM	TCGA	HRLLLLFLV	DEG_APCC_DBOX_1	0.1944
p.L35M	DO37831	SKCM	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.1944
p.L21I	DO222884	COCA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.3056
p.R23C	DO233088	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.8301
p.R23C	DO233944	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.8301
p.R23C	DO228963	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.8301
p.L26M	DO233272	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.711
p.G12C	DO233944	GACA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.0556
p.P29Q	DO20917	KIRP	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.7035
p.T34N	DO228900	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2222
p.T34N	DO229024	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2222
p.R23S	DO228985	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.7427
p.Q34K	DO229029	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2222
p.L15I	DO229028	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.1389
p.V30I	DO50970	LICA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.5965
p.M36V	DO45073	LINC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.1667
p.G12V	DO23508	LIRI	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.0556
p.K24R	DO26042	LUAD	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.7237
p.G39A	DO27612	LUSC	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.0833
p.P29S	DO229459	SKCA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.6752
p.M32I	DO218856	SKCA	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.P17L	DO51237	SKCM	ICGC	HRLLLLFLV	DEG_APCC_DBOX_1	0.1944
p.R20C	SIDM01943	Colorectal Carcinoma	GDSC	HRLLLLFLV	DEG_APCC_DBOX_1	0.2778
p.L35R	SIDM01078	Small Cell Lung Carcinoma	GDSC	HRLLLLFLV	DEG_APCC_DBOX_1	0.1944
p.L35R	ACH-000790	Lung Cancer	CCLE	HRLLLLFLV	DEG_APCC_DBOX_1	0.1944
p.L35R	SHP-77	lung	COSMIC	HRLLLLFLV	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRLLLLFLV

Degron related mutations and impact score

Drug responses associated with NUP210L mutations

All proteins holding degron of HRLLLLFLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VU65	Nuclear pore membrane glycoprotein 210-like	DEG_APCC_DBOX_1	22:30	HRLLLLFLV	APC,CDC20,FZR1	0.7105	More...