DegronMD

Uniprot ID: O00429

Source protein: Dynamin-1-like protein

Source gene: DNM1L

Class: DEG_COP1_1

Location: 531:539

E3 ligase: COP1

DEGRON score: 0.9951

ASA_SCORE: 83.9889

COIL: 0.7911

CONS_SCORE: 0.209

DSS_SCORE: 0.6386

HELIX: 0.1651

FCONS_SCORE: 1.0561

RIG_SCORE: 0.6053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D531A	TCGA-A5-A0G2	UCEC	TCGA	DKSSKVPSA	DEG_COP1_1	0.7793
p.S534C	TCGA-CV-6441	HNSC	TCGA	DKSSKVPSA	DEG_COP1_1	0.643
p.S534C	DO14254	HNSC	ICGC	DKSSKVPSA	DEG_COP1_1	0.643
p.S533F	TCGA-DR-A0ZM	CESC	TCGA	DKSSKVPSA	DEG_COP1_1	0.7982
p.S533F	DO6254	CESC	ICGC	DKSSKVPSA	DEG_COP1_1	0.7982
p.S533F	DO231031	LUSC	ICGC	DKSSKVPSA	DEG_COP1_1	0.7982
p.R522K	TCGA-J1-A4AH	LUSC	TCGA	DKSSKVPSA	DEG_COP1_1	0.0833
p.S539L	DO48408	BLCA	ICGC	DKSSKVPSA	DEG_COP1_1	0.7667
p.D544H	DO233192	GACA	ICGC	DKSSKVPSA	DEG_COP1_1	0.6389
p.R530I	DO13863	GBM	ICGC	DKSSKVPSA	DEG_COP1_1	0.3056
p.A539S	DO228976	LICA	ICGC	DKSSKVPSA	DEG_COP1_1	0.7588
p.A541S	DO229031	LICA	ICGC	DKSSKVPSA	DEG_COP1_1	0.2778
p.A540S	DO229038	LICA	ICGC	DKSSKVPSA	DEG_COP1_1	0.3056
p.S548F	DO23186	LINC	ICGC	DKSSKVPSA	DEG_COP1_1	0.5278
p.R535K	DO45479	LUSC	ICGC	DKSSKVPSA	DEG_COP1_1	0.7237
p.R532M	DO51785	STAD	ICGC	DKSSKVPSA	DEG_COP1_1	0.8632
p.S548Y	DO229208	THCA	ICGC	DKSSKVPSA	DEG_COP1_1	0.5278
p.S548Y	DO229234	THCA	ICGC	DKSSKVPSA	DEG_COP1_1	0.5278
p.E536D	DO229208	THCA	ICGC	DKSSKVPSA	DEG_COP1_1	0.6758
p.D544A	DO41235	UCEC	ICGC	DKSSKVPSA	DEG_COP1_1	0.6389
p.G549E	DO42713	UCEC	ICGC	DKSSKVPSA	DEG_COP1_1	0.0556
p.N531I	DO42713	UCEC	ICGC	DKSSKVPSA	DEG_COP1_1	0.728
p.I525T	SIDM00399	Head and Neck Carcinoma	GDSC	DKSSKVPSA	DEG_COP1_1	0.1667
p.I525T	SCC90	upper_aerodigestive_tract	COSMIC	DKSSKVPSA	DEG_COP1_1	0.1667
p.R535T	SIDM01735	Biliary Tract Carcinoma	GDSC	DKSSKVPSA	DEG_COP1_1	0.7876
p.R522T	ACH-000808	Bile Duct Cancer	CCLE	DKSSKVPSA	DEG_COP1_1	0.0833
p.Q522E	SW756	cervix	COSMIC	DKSSKVPSA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00429	Dynamin-1-like protein	DEG_COP1_1	531:539	DKSSKVPSA	COP1	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons