DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: CBL_PTK

Location: 5240:5246

E3 ligase: CBL

DEGRON score: 0.9543

ASA_SCORE: 76.5

COIL: 0.8679

CONS_SCORE: 0.6021

DSS_SCORE: 0.3449

HELIX: 0.0649

FCONS_SCORE: 0.9494

RIG_SCORE: 0.7915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I5233M	DO36881	READ	ICGC	DKYTPVP	CBL_PTK	0.1389
p.I5252V	ACH-000994	Endometrial/Uterine Cancer	CCLE	DKYTPVP	CBL_PTK	0.1667
p.P5244S	GP5d	large_intestine	COSMIC	DKYTPVP	CBL_PTK	0.5641
p.P5244S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	DKYTPVP	CBL_PTK	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20929	Nebulin	CBL_PTK	5240:5246	DKYTPVP	CBL	0.9543	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons