DegronMD - P20929(NEB)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S398I	TCGA-17-Z030	LUAD	TCGA	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1389
p.S398I	TCGA-AX-A05Z	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1389
p.S398I	DO40884	UCEC	ICGC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1389
p.W6276G	TCGA-53-7624	LUAD	TCGA	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.2778
p.V6220A	TCGA-63-5128	LUSC	TCGA	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation altering degron motif	0.6936
p.P225A	TCGA-69-A59K	LUAD	TCGA	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.2778
p.P225A	DO45335	LUAD	ICGC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.2778
p.Q6275K	TCGA-AB-2871	LAML	TCGA	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.25
p.R6289Q	TCGA-AG-A002	READ	TCGA	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7329
p.R6289Q	TCGA-B5-A0K9	UCEC	TCGA	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7329
p.R6289Q	SIDM01274	Esophageal Carcinoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7329
p.E6372V	TCGA-AX-A0J0	UCEC	TCGA	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7693
p.Y6374H	TCGA-BS-A0UF	UCEC	TCGA	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7229
p.N6373S	TCGA-CA-6717	COAD	TCGA	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7069
p.N6373S	DO8264	COAD	ICGC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7069
p.N222T	TCGA-CA-6718	COAD	TCGA	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.5944
p.N222T	DO7801	COAD	ICGC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.5944
p.E389K	TCGA-D9-A3Z3	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation altering degron motif	0.7022
p.E389K	TCGA-EB-A44O	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation altering degron motif	0.7022
p.E389K	DO37563	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation altering degron motif	0.7022
p.E389K	DO47272	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation altering degron motif	0.7022
p.D6250Y	TCGA-DF-A2KU	UCEC	TCGA	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation altering degron motif	0.7325
p.D6250Y	DO223286	UCEC	ICGC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation altering degron motif	0.7325
p.E6281K	TCGA-EB-A4IS	SKCM	TCGA	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation altering degron motif	0.7022
p.E6281K	DO47281	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation altering degron motif	0.7022
p.E6372K	TCGA-EE-A3J5	SKCM	TCGA	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7022
p.R6270Q	TCGA-EO-A22R	UCEC	TCGA	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.1111
p.D6302Y	TCGA-EO-A22U	UCEC	TCGA	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation rewiring degron network	0.1389
p.N6290H	TCGA-EO-A3B0	UCEC	TCGA	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7423
p.N6290H	DO219773	UCEC	ICGC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7423
p.E389D	TCGA-EY-A1GI	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation altering degron motif	0.6758
p.E389D	DO41211	UCEC	ICGC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation altering degron motif	0.6758
p.Y6272H	TCGA-F7-A624	HNSC	TCGA	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.1667
p.Y6272H	DO44440	HNSC	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.1667
p.L6223M	TCGA-FD-A5C0	BLCA	TCGA	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.25
p.L6223M	DO44046	BLCA	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.25
p.E392K	TCGA-W3-AA1R	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.3056
p.E392K	DO51275	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.3056
p.H6221Y	TCGA-ZF-AA4W	BLCA	TCGA	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.3056
p.E6280Q	DO219007	BLCA	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation altering degron motif	0.6744
p.Q6208H	DO465	BLCA	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.1111
p.S6361N	DO228306	BRCA	ICGC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation rewiring degron network	0.0556
p.E4426D	DO8842	COAD	ICGC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation rewiring degron network	0.25
p.L6251S	DO230312	COCA	ICGC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation altering degron motif	0.6556
p.L6220V	DO50447	ESAD	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation altering degron motif	0.5654
p.P225L	DO48195	ESCA	ICGC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.2778
p.N6373K	DO233170	GACA	ICGC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.6918
p.A6209T	DO233935	GACA	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation substituting flanking lysine	0.25
p.V6220G	DO233906	GACA	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation altering degron motif	0.7532
p.N6373Y	DO228203	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7059
p.Y6278F	DO231940	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation altering degron motif	0.7528
p.R6268S	DO231951	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.0556
p.T6257K	DO228900	LICA	ICGC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation blocking phosphorylation signal	0.6111
p.P4442Q	DO228952	LICA	ICGC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation rewiring degron network	0.25
p.Q6208K	DO229029	LICA	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.1111
p.A213E	DO229026	LICA	ICGC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.1944
p.S6274R	DO229038	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.2222
p.A377E	DO229037	LICA	ICGC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.0556
p.T394K	DO229006	LICA	ICGC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.25
p.Y4424H	DO231713	LINC	ICGC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation rewiring degron network	0.1944
p.Y4424H	DO40884	UCEC	ICGC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation rewiring degron network	0.1944
p.P6380Q	DO23774	LUAD	ICGC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation rewiring degron network	0.1944
p.P6380Q	DO47578	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation rewiring degron network	0.1944
p.R6237S	DO219127	LUSC	ICGC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation rewiring degron network	0.0556
p.K6279R	DO52021	LUSC	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation altering degron motif	0.7237
p.A6291T	DO228338	MALY	ICGC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7139
p.A6291T	SIDM00948	Burkitt's Lymphoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7139
p.A6291T	ACH-002232	Lymphoma	CCLE	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7139
p.A6291T	DG-75	haematopoietic and lymphoid tissue	COSMIC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7139
p.D6224N	DO220885	MELA	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.2222
p.R6268H	DO48889	PBCA	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.0556
p.T6222A	DO36937	READ	ICGC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.2778
p.I5233M	DO36881	READ	ICGC	DKYTPVP	CBL_PTK	5240:5246	Mutation rewiring degron network	0.1389
p.G6252E	DO37551	SKCM	ICGC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation rewiring degron network	0.3056
p.E4426K	DO37831	SKCM	ICGC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation rewiring degron network	0.25
p.E6280V	DO37831	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation altering degron motif	0.7693
p.P6382H	DO37487	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation rewiring degron network	0.1389
p.G6254E	DO50301	SKCM	ICGC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation rewiring degron network	0.25
p.E6295K	DO223286	UCEC	ICGC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7022
p.S6275L	DO42793	UCEC	ICGC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.25
p.R6287C	SIDM02077	Colorectal Carcinoma	GDSC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.1944
p.R6287C	SIDM02077	Colorectal Carcinoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation rewiring degron network	0.3056
p.G379E	SIDM00545	Melanoma	GDSC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1111
p.G379E	ACH-000987	Skin Cancer	CCLE	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1111
p.G379E	Mewo	skin	COSMIC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1111
p.A6209D	SIDM00504	Glioma	GDSC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation substituting flanking lysine	0.25
p.A6209D	ACH-001126	Brain Cancer	CCLE	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation substituting flanking lysine	0.25
p.A6209D	MOG-G-UVW	central nervous system	COSMIC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation substituting flanking lysine	0.25
p.S398N	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1389
p.S398N	ACH-000718	Lung Cancer	CCLE	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1389
p.S398N	NCI-H2291	lung	COSMIC	YKENY	DEG_APCC_KENBOX_2	387:391	Mutation rewiring degron network	0.1389
p.D223E	SIDM00789	Colorectal Carcinoma	GDSC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.5647
p.D223E	ACH-000997	Colon/Colorectal Cancer	CCLE	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.5647
p.D223E	ACH-001061	Colon/Colorectal Cancer	CCLE	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.5647
p.D223E	HCT-15	large intestine	COSMIC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.5647
p.E6372G	SIDM00193	Colorectal Carcinoma	GDSC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7199
p.E6372G	ACH-000991	Colon/Colorectal Cancer	CCLE	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7199
p.E6372G	SNU-81	large intestine	COSMIC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation altering degron motif	0.7199
p.V6288I	SIDM00799	Glioblastoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	6288:6295	Mutation altering degron motif	0.7076
p.L6208V	SIDM00276	Biliary Tract Carcinoma	GDSC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.1111
p.L6208V	SIDM01435	Hepatocellular Carcinoma	GDSC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.1111
p.L6208V	ETK-1	biliary tract	COSMIC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.1111
p.P220L	SIDM01064	Hodgkin's Lymphoma	GDSC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.6471
p.P220L	ACH-000267	Lymphoma	CCLE	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.6471
p.P220L	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation altering degron motif	0.6471
p.G6218D	SIDM00793	Burkitt's Lymphoma	GDSC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation altering degron motif	0.7198
p.I5252V	ACH-000994	Endometrial/Uterine Cancer	CCLE	DKYTPVP	CBL_PTK	5240:5246	Mutation rewiring degron network	0.1667
p.T208A	ACH-001970	Metastasis	CCLE	FYPYND	LIG_APCC_ABBA_1	218:223	Mutation rewiring degron network	0.0556
p.K4432R	ES4	bone	COSMIC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation altering degron motif	0.6126
p.D4449Y	SNU-81	large intestine	COSMIC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation rewiring degron network	0.0556
p.P6380L	SNU-1040	large intestine	COSMIC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation rewiring degron network	0.1944
p.N6272K	HCC70	breast	COSMIC	YKENM	DEG_APCC_KENBOX_2	6278:6282	Mutation rewiring degron network	0.1667
p.P5244S	GP5d	large intestine	COSMIC	DKYTPVP	CBL_PTK	5240:5246	Mutation altering degron motif	0.5641
p.P5244S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	DKYTPVP	CBL_PTK	5240:5246	Mutation altering degron motif	0.5641
p.Y4435S	HCC2998	large intestine	COSMIC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation altering degron motif	0.712
p.V6369I	MDA-MB-231	breast	COSMIC	YKENM	DEG_APCC_KENBOX_2	6371:6375	Mutation rewiring degron network	0.2778
p.E6249D	ESS-1	endometrium	COSMIC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation altering degron motif	0.6758
p.I6211T	CW-2	large intestine	COSMIC	YKENL	DEG_APCC_KENBOX_2	6216:6220	Mutation rewiring degron network	0.1944
p.Q6239H	CESS	haematopoietic and lymphoid tissue	COSMIC	YKENL	DEG_APCC_KENBOX_2	6247:6251	Mutation rewiring degron network	0.1111
p.S4438L	MZ7-mel	skin	COSMIC	NKAKGKYTFSP	CBL_PTK	4429:4439	Mutation altering degron motif	0.6556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEB

UniProt ID: P20929

Entrez ID: 4703

Protein name: Nebulin

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NEB in