DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: DEG_APCC_KENBOX_2

Location: 6216:6220

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7938

ASA_SCORE: 94.2

COIL: 0.715

CONS_SCORE: 0.3634

DSS_SCORE: 0.4548

HELIX: 0.104

FCONS_SCORE: 0.9756

RIG_SCORE: 0.7462

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V6220A	TCGA-63-5128	LUSC	TCGA	YKENL	DEG_APCC_KENBOX_2	0.6936
p.L6223M	TCGA-FD-A5C0	BLCA	TCGA	YKENL	DEG_APCC_KENBOX_2	0.25
p.L6223M	DO44046	BLCA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.25
p.H6221Y	TCGA-ZF-AA4W	BLCA	TCGA	YKENL	DEG_APCC_KENBOX_2	0.3056
p.Q6208H	DO465	BLCA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.1111
p.L6220V	DO50447	ESAD	ICGC	YKENL	DEG_APCC_KENBOX_2	0.5654
p.A6209T	DO233935	GACA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.25
p.V6220G	DO233906	GACA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.7532
p.Q6208K	DO229029	LICA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.1111
p.D6224N	DO220885	MELA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.2222
p.T6222A	DO36937	READ	ICGC	YKENL	DEG_APCC_KENBOX_2	0.2778
p.A6209D	SIDM00504	Glioma	GDSC	YKENL	DEG_APCC_KENBOX_2	0.25
p.A6209D	ACH-001126	Brain Cancer	CCLE	YKENL	DEG_APCC_KENBOX_2	0.25
p.A6209D	MOG-G-UVW	central_nervous_system	COSMIC	YKENL	DEG_APCC_KENBOX_2	0.25
p.L6208V	SIDM00276	Biliary Tract Carcinoma	GDSC	YKENL	DEG_APCC_KENBOX_2	0.1111
p.L6208V	SIDM01435	Hepatocellular Carcinoma	GDSC	YKENL	DEG_APCC_KENBOX_2	0.1111
p.L6208V	ETK-1	biliary_tract	COSMIC	YKENL	DEG_APCC_KENBOX_2	0.1111
p.G6218D	SIDM00793	Burkitt's Lymphoma	GDSC	YKENL	DEG_APCC_KENBOX_2	0.7198
p.I6211T	CW-2	large_intestine	COSMIC	YKENL	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18615	Negative elongation factor E	DEG_APCC_KENBOX_2	372:376	YKENL	APC,CDC20,FZR1	0.7548	More...
P20929	Nebulin	DEG_APCC_KENBOX_2	6216:6220	YKENL	APC,CDC20,FZR1	0.7938	More...
P20929	Nebulin	DEG_APCC_KENBOX_2	6247:6251	YKENL	APC,CDC20,FZR1	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons