DegronMD - P18615(NELFE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S89C	TCGA-A3-A6NN	KIRC	TCGA	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation blocking phosphorylation signal	0.5278
p.T263A	TCGA-A6-6780	COAD	TCGA	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.3056
p.R112T	TCGA-C5-A8XK	CESC	TCGA	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation rewiring degron network	0.1944
p.R88C	TCGA-CD-A4MG	STAD	TCGA	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation rewiring degron network	0.0556
p.R88C	TCGA-EY-A1GI	UCEC	TCGA	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation rewiring degron network	0.0556
p.Y372C	TCGA-EO-A22U	UCEC	TCGA	YKENL	DEG_APCC_KENBOX_2	372:376	Mutation altering degron motif	0.7087
p.L376F	TCGA-IB-7651	PAAD	TCGA	YKENL	DEG_APCC_KENBOX_2	372:376	Mutation altering degron motif	0.587
p.R256Q	TCGA-L5-A8NQ	ESCA	TCGA	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.1111
p.E93Q	TCGA-MF-A522	LUSC	TCGA	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation rewiring degron network	0.1944
p.R255W	TCGA-OR-A5JM	ACC	TCGA	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.0833
p.R277H	TCGA-RS-A6TO	HNSC	TCGA	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.1111
p.R277H	SIDM01561	Melanoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.1111
p.R277H	ACH-000799	Skin Cancer	CCLE	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.1111
p.T270A	DO10244	COAD	ICGC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.3056
p.R95C	DO227984	COCA	ICGC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation blocking ubiquitination signal	0.6944
p.R95C	DO48009	STAD	ICGC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation blocking ubiquitination signal	0.6944
p.R95C	DO41211	UCEC	ICGC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation blocking ubiquitination signal	0.6944
p.R266M	DO222755	COCA	ICGC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation altering degron motif	0.8632
p.S96C	DO219230	KIRC	ICGC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation rewiring degron network	0.2778
p.E100Q	DO45526	LUSC	ICGC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation altering degron motif	0.6744
p.L383F	DO46657	PAAD	ICGC	YKENL	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.1389
p.D257E	DO37671	SKCM	ICGC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.1389
p.S258L	DO37671	SKCM	ICGC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.1667
p.Y379C	DO43755	UCEC	ICGC	YKENL	DEG_APCC_KENBOX_2	372:376	Mutation rewiring degron network	0.25
p.R255Q	SIDM00216	Colorectal Carcinoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.0833
p.R255Q	SNU-175	large intestine	COSMIC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.0833
p.G261R	SIDM00025	Head and Neck Carcinoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.25
p.G261R	UDSCC2	upper aerodigestive tract	COSMIC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.25
p.R255L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.0833
p.R255L	ACH-000875	Lung Cancer	CCLE	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.0833
p.R255L	NCI-H2347	lung	COSMIC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.0833
p.V104L	SIDM00760	Small Cell Lung Carcinoma	GDSC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation altering degron motif	0.6765
p.V104L	ACH-000729	Lung Cancer	CCLE	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation altering degron motif	0.6765
p.V104L	NCI-H1963	lung	COSMIC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation altering degron motif	0.6765
p.G268R	UDSCC2	upper aerodigestive tract	COSMIC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation altering degron motif	0.6457
p.R262L	NCI-H2347	lung	COSMIC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.2778
p.R262Q	SNU-175	large intestine	COSMIC	LYVYGE	LIG_APCC_ABBA_1	264:269	Mutation rewiring degron network	0.2778
p.V111L	NCI-H1963	lung	COSMIC	DPEKGPVPTF	DEG_COP1_1	98:107	Mutation rewiring degron network	0.2222

Kaplan plot for NELFE in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NELFE

UniProt ID: P18615

Entrez ID: 7936

Protein name: Negative elongation factor E (NELF-E) (RNA-binding protein RD)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NELFE in