DegronMD

Uniprot ID: P18615

Source protein: Negative elongation factor E

Source gene: NELFE

Class: DEG_COP1_1

Location: 98:107

E3 ligase: COP1

DEGRON score: 0.9581

ASA_SCORE: 85.04

COIL: 0.9068

CONS_SCORE: 0.4754

DSS_SCORE: 0.6653

HELIX: 0.0466

FCONS_SCORE: 0.898

RIG_SCORE: 0.645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S89C	TCGA-A3-A6NN	KIRC	TCGA	DPEKGPVPTF	DEG_COP1_1	0.5278
p.R112T	TCGA-C5-A8XK	CESC	TCGA	DPEKGPVPTF	DEG_COP1_1	0.1944
p.R88C	TCGA-CD-A4MG	STAD	TCGA	DPEKGPVPTF	DEG_COP1_1	0.0556
p.R88C	TCGA-EY-A1GI	UCEC	TCGA	DPEKGPVPTF	DEG_COP1_1	0.0556
p.E93Q	TCGA-MF-A522	LUSC	TCGA	DPEKGPVPTF	DEG_COP1_1	0.1944
p.R95C	DO227984	COCA	ICGC	DPEKGPVPTF	DEG_COP1_1	0.6944
p.R95C	DO48009	STAD	ICGC	DPEKGPVPTF	DEG_COP1_1	0.6944
p.R95C	DO41211	UCEC	ICGC	DPEKGPVPTF	DEG_COP1_1	0.6944
p.S96C	DO219230	KIRC	ICGC	DPEKGPVPTF	DEG_COP1_1	0.2778
p.E100Q	DO45526	LUSC	ICGC	DPEKGPVPTF	DEG_COP1_1	0.6744
p.V104L	SIDM00760	Small Cell Lung Carcinoma	GDSC	DPEKGPVPTF	DEG_COP1_1	0.6765
p.V104L	ACH-000729	Lung Cancer	CCLE	DPEKGPVPTF	DEG_COP1_1	0.6765
p.V104L	NCI-H1963	lung	COSMIC	DPEKGPVPTF	DEG_COP1_1	0.6765
p.V111L	NCI-H1963	lung	COSMIC	DPEKGPVPTF	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18615	Negative elongation factor E	DEG_COP1_1	98:107	DPEKGPVPTF	COP1	0.9581	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons