DegronMD

Uniprot ID: P18615

Source protein: Negative elongation factor E

Source gene: NELFE

Class: DEG_APCC_KENBOX_2

Location: 372:376

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7548

ASA_SCORE: 87.16

COIL: 0.5078

CONS_SCORE: 0.2365

DSS_SCORE: 0.4486

HELIX: 0.3846

FCONS_SCORE: 0.7611

RIG_SCORE: 0.8372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y372C	TCGA-EO-A22U	UCEC	TCGA	YKENL	DEG_APCC_KENBOX_2	0.7087
p.L376F	TCGA-IB-7651	PAAD	TCGA	YKENL	DEG_APCC_KENBOX_2	0.587
p.L383F	DO46657	PAAD	ICGC	YKENL	DEG_APCC_KENBOX_2	0.1389
p.Y379C	DO43755	UCEC	ICGC	YKENL	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18615	Negative elongation factor E	DEG_APCC_KENBOX_2	372:376	YKENL	APC,CDC20,FZR1	0.7548	More...
P20929	Nebulin	DEG_APCC_KENBOX_2	6216:6220	YKENL	APC,CDC20,FZR1	0.7938	More...
P20929	Nebulin	DEG_APCC_KENBOX_2	6247:6251	YKENL	APC,CDC20,FZR1	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons