DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: DEG_APCC_KENBOX_2

Location: 6247:6251

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9775

ASA_SCORE: 80.86

COIL: 0.5948

CONS_SCORE: 0.3593

DSS_SCORE: 0.4441

HELIX: 0.0656

FCONS_SCORE: 0.9918

RIG_SCORE: 0.7696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D6250Y	TCGA-DF-A2KU	UCEC	TCGA	YKENL	DEG_APCC_KENBOX_2	0.7325
p.D6250Y	DO223286	UCEC	ICGC	YKENL	DEG_APCC_KENBOX_2	0.7325
p.L6251S	DO230312	COCA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.6556
p.T6257K	DO228900	LICA	ICGC	YKENL	DEG_APCC_KENBOX_2	0.6111
p.R6237S	DO219127	LUSC	ICGC	YKENL	DEG_APCC_KENBOX_2	0.0556
p.G6252E	DO37551	SKCM	ICGC	YKENL	DEG_APCC_KENBOX_2	0.3056
p.G6254E	DO50301	SKCM	ICGC	YKENL	DEG_APCC_KENBOX_2	0.25
p.E6249D	ESS-1	endometrium	COSMIC	YKENL	DEG_APCC_KENBOX_2	0.6758
p.Q6239H	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	YKENL	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18615	Negative elongation factor E	DEG_APCC_KENBOX_2	372:376	YKENL	APC,CDC20,FZR1	0.7548	More...
P20929	Nebulin	DEG_APCC_KENBOX_2	6216:6220	YKENL	APC,CDC20,FZR1	0.7938	More...
P20929	Nebulin	DEG_APCC_KENBOX_2	6247:6251	YKENL	APC,CDC20,FZR1	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons