DegronMD

Uniprot ID: P18615

Source protein: Negative elongation factor E

Source gene: NELFE

Class: LIG_APCC_ABBA_1

Location: 264:269

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9322

ASA_SCORE: 47.7667

COIL: 0.3868

CONS_SCORE: 0.5846

DSS_SCORE: 0.4011

HELIX: 0.0165

FCONS_SCORE: 1.1914

RIG_SCORE: 0.801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T263A	TCGA-A6-6780	COAD	TCGA	LYVYGE	LIG_APCC_ABBA_1	0.3056
p.R256Q	TCGA-L5-A8NQ	ESCA	TCGA	LYVYGE	LIG_APCC_ABBA_1	0.1111
p.R255W	TCGA-OR-A5JM	ACC	TCGA	LYVYGE	LIG_APCC_ABBA_1	0.0833
p.R277H	TCGA-RS-A6TO	HNSC	TCGA	LYVYGE	LIG_APCC_ABBA_1	0.1111
p.R277H	SIDM01561	Melanoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	0.1111
p.R277H	ACH-000799	Skin Cancer	CCLE	LYVYGE	LIG_APCC_ABBA_1	0.1111
p.T270A	DO10244	COAD	ICGC	LYVYGE	LIG_APCC_ABBA_1	0.3056
p.R266M	DO222755	COCA	ICGC	LYVYGE	LIG_APCC_ABBA_1	0.8632
p.D257E	DO37671	SKCM	ICGC	LYVYGE	LIG_APCC_ABBA_1	0.1389
p.S258L	DO37671	SKCM	ICGC	LYVYGE	LIG_APCC_ABBA_1	0.1667
p.R255Q	SIDM00216	Colorectal Carcinoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	0.0833
p.R255Q	SNU-175	large_intestine	COSMIC	LYVYGE	LIG_APCC_ABBA_1	0.0833
p.G261R	SIDM00025	Head and Neck Carcinoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	0.25
p.G261R	UDSCC2	upper_aerodigestive_tract	COSMIC	LYVYGE	LIG_APCC_ABBA_1	0.25
p.R255L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	LYVYGE	LIG_APCC_ABBA_1	0.0833
p.R255L	ACH-000875	Lung Cancer	CCLE	LYVYGE	LIG_APCC_ABBA_1	0.0833
p.R255L	NCI-H2347	lung	COSMIC	LYVYGE	LIG_APCC_ABBA_1	0.0833
p.G268R	UDSCC2	upper_aerodigestive_tract	COSMIC	LYVYGE	LIG_APCC_ABBA_1	0.6457
p.R262L	NCI-H2347	lung	COSMIC	LYVYGE	LIG_APCC_ABBA_1	0.2778
p.R262Q	SNU-175	large_intestine	COSMIC	LYVYGE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18615	Negative elongation factor E	LIG_APCC_ABBA_1	264:269	LYVYGE	APC,CDC20,FZR1	0.9322	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons