DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: LIG_APCC_ABBA_1

Location: 218:223

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.808

ASA_SCORE: 61.1667

COIL: 0.8312

CONS_SCORE: 0.7031

DSS_SCORE: 0.2923

HELIX: 0.0542

FCONS_SCORE: 0.9971

RIG_SCORE: 0.8143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P225A	TCGA-69-A59K	LUAD	TCGA	FYPYND	LIG_APCC_ABBA_1	0.2778
p.P225A	DO45335	LUAD	ICGC	FYPYND	LIG_APCC_ABBA_1	0.2778
p.N222T	TCGA-CA-6718	COAD	TCGA	FYPYND	LIG_APCC_ABBA_1	0.5944
p.N222T	DO7801	COAD	ICGC	FYPYND	LIG_APCC_ABBA_1	0.5944
p.P225L	DO48195	ESCA	ICGC	FYPYND	LIG_APCC_ABBA_1	0.2778
p.A213E	DO229026	LICA	ICGC	FYPYND	LIG_APCC_ABBA_1	0.1944
p.D223E	SIDM00789	Colorectal Carcinoma	GDSC	FYPYND	LIG_APCC_ABBA_1	0.5647
p.D223E	ACH-000997	Colon/Colorectal Cancer	CCLE	FYPYND	LIG_APCC_ABBA_1	0.5647
p.D223E	ACH-001061	Colon/Colorectal Cancer	CCLE	FYPYND	LIG_APCC_ABBA_1	0.5647
p.D223E	HCT-15	large_intestine	COSMIC	FYPYND	LIG_APCC_ABBA_1	0.5647
p.P220L	SIDM01064	Hodgkin's Lymphoma	GDSC	FYPYND	LIG_APCC_ABBA_1	0.6471
p.P220L	ACH-000267	Lymphoma	CCLE	FYPYND	LIG_APCC_ABBA_1	0.6471
p.P220L	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	FYPYND	LIG_APCC_ABBA_1	0.6471
p.T208A	ACH-001970	Metastasis	CCLE	FYPYND	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20929	Nebulin	LIG_APCC_ABBA_1	218:223	FYPYND	APC,CDC20,FZR1	0.808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons