DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: DEG_APCC_KENBOX_2

Location: 387:391

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5213

ASA_SCORE: 82.08

COIL: 0.3954

CONS_SCORE: 0.7277

DSS_SCORE: 0.3352

HELIX: 0.5524

FCONS_SCORE: 1.0999

RIG_SCORE: 0.7891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S398I	TCGA-17-Z030	LUAD	TCGA	YKENY	DEG_APCC_KENBOX_2	0.1389
p.S398I	TCGA-AX-A05Z	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	0.1389
p.S398I	DO40884	UCEC	ICGC	YKENY	DEG_APCC_KENBOX_2	0.1389
p.E389K	TCGA-D9-A3Z3	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	0.7022
p.E389K	TCGA-EB-A44O	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	0.7022
p.E389K	DO37563	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	0.7022
p.E389K	DO47272	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	0.7022
p.E389D	TCGA-EY-A1GI	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	0.6758
p.E389D	DO41211	UCEC	ICGC	YKENY	DEG_APCC_KENBOX_2	0.6758
p.E392K	TCGA-W3-AA1R	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	0.3056
p.E392K	DO51275	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	0.3056
p.A377E	DO229037	LICA	ICGC	YKENY	DEG_APCC_KENBOX_2	0.0556
p.T394K	DO229006	LICA	ICGC	YKENY	DEG_APCC_KENBOX_2	0.25
p.G379E	SIDM00545	Melanoma	GDSC	YKENY	DEG_APCC_KENBOX_2	0.1111
p.G379E	ACH-000987	Skin Cancer	CCLE	YKENY	DEG_APCC_KENBOX_2	0.1111
p.G379E	Mewo	skin	COSMIC	YKENY	DEG_APCC_KENBOX_2	0.1111
p.S398N	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	YKENY	DEG_APCC_KENBOX_2	0.1389
p.S398N	ACH-000718	Lung Cancer	CCLE	YKENY	DEG_APCC_KENBOX_2	0.1389
p.S398N	NCI-H2291	lung	COSMIC	YKENY	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20929	Nebulin	DEG_APCC_KENBOX_2	387:391	YKENY	APC,CDC20,FZR1	0.5213	More...
Q86VF7	Nebulin-related-anchoring protein	DEG_APCC_KENBOX_2	408:412	YKENY	APC,CDC20,FZR1	0.7468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons