DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
YKENY
Uniprot ID:
Q86VF7
Source protein:
Nebulin-related-anchoring protein
Source gene:
NRAP
Class:
DEG_APCC_KENBOX_2
Location:
408:412
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7468
ASA_SCORE:
82.72
COIL:
0.4058
CONS_SCORE:
0.8313
DSS_SCORE:
0.4649
HELIX:
0.5424
FCONS_SCORE:
1.0856
RIG_SCORE:
0.7632
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E421K
TCGA-2Z-A9JQ
KIRP
TCGA
YKENY
DEG_APCC_KENBOX_2
0.0833
p.F402S
TCGA-56-7731
LUSC
TCGA
YKENY
DEG_APCC_KENBOX_2
0.1667
p.F402S
DO45527
LUSC
ICGC
YKENY
DEG_APCC_KENBOX_2
0.1667
p.M416T
TCGA-AG-3891
READ
TCGA
YKENY
DEG_APCC_KENBOX_2
0.2222
p.R419C
TCGA-DU-6392
LGG
TCGA
YKENY
DEG_APCC_KENBOX_2
0.1389
p.R419C
TCGA-EO-A22R
UCEC
TCGA
YKENY
DEG_APCC_KENBOX_2
0.1389
p.R419H
TCGA-EY-A548
UCEC
TCGA
YKENY
DEG_APCC_KENBOX_2
0.1389
p.R419H
TCGA-FG-6688
LGG
TCGA
YKENY
DEG_APCC_KENBOX_2
0.1389
p.G422R
TCGA-GN-A26A
SKCM
TCGA
YKENY
DEG_APCC_KENBOX_2
0.0556
p.A408T
DO230326
COCA
ICGC
YKENY
DEG_APCC_KENBOX_2
0.7139
p.V407A
DO222884
COCA
ICGC
YKENY
DEG_APCC_KENBOX_2
0.3056
p.Y422S
DO219881
SKCA
ICGC
YKENY
DEG_APCC_KENBOX_2
0.0556
p.D416Y
DO37896
SKCM
ICGC
YKENY
DEG_APCC_KENBOX_2
0.2222
p.V400A
DO47274
SKCM
ICGC
YKENY
DEG_APCC_KENBOX_2
0.1111
Drug responses associated with NRAP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of YKENY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P20929
Nebulin
DEG_APCC_KENBOX_2
387:391
YKENY
APC,CDC20,FZR1
0.5213
More...
Q86VF7
Nebulin-related-anchoring protein
DEG_APCC_KENBOX_2
408:412
YKENY
APC,CDC20,FZR1
0.7468
More...