DegronMD

Uniprot ID: Q86VF7

Source protein: Nebulin-related-anchoring protein

Source gene: NRAP

Class: DEG_APCC_KENBOX_2

Location: 408:412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7468

ASA_SCORE: 82.72

COIL: 0.4058

CONS_SCORE: 0.8313

DSS_SCORE: 0.4649

HELIX: 0.5424

FCONS_SCORE: 1.0856

RIG_SCORE: 0.7632

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A408T	DO230326	COCA	ICGC	YKENY	DEG_APCC_KENBOX_2	0.7139
p.V407A	DO222884	COCA	ICGC	YKENY	DEG_APCC_KENBOX_2	0.3056
p.M416T	TCGA-AG-3891	READ	TCGA	YKENY	DEG_APCC_KENBOX_2	0.2222
p.D416Y	DO37896	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	0.2222
p.F402S	TCGA-56-7731	LUSC	TCGA	YKENY	DEG_APCC_KENBOX_2	0.1667
p.F402S	DO45527	LUSC	ICGC	YKENY	DEG_APCC_KENBOX_2	0.1667
p.R419C	TCGA-DU-6392	LGG	TCGA	YKENY	DEG_APCC_KENBOX_2	0.1389
p.R419C	TCGA-EO-A22R	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	0.1389
p.R419H	TCGA-EY-A548	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	0.1389
p.R419H	TCGA-FG-6688	LGG	TCGA	YKENY	DEG_APCC_KENBOX_2	0.1389
p.V400A	DO47274	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	0.1111
p.E421K	TCGA-2Z-A9JQ	KIRP	TCGA	YKENY	DEG_APCC_KENBOX_2	0.0833
p.G422R	TCGA-GN-A26A	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	0.0556
p.Y422S	DO219881	SKCA	ICGC	YKENY	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20929	Nebulin	DEG_APCC_KENBOX_2	387:391	YKENY	APC,CDC20,FZR1	0.5213	More...
Q86VF7	Nebulin-related-anchoring protein	DEG_APCC_KENBOX_2	408:412	YKENY	APC,CDC20,FZR1	0.7468	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons