DegronMD - Q86VF7(NRAP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1670A	TCGA-17-Z001	LUAD	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation altering degron motif	0.6392
p.E421K	TCGA-2Z-A9JQ	KIRP	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.0833
p.F402S	TCGA-56-7731	LUSC	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.1667
p.F402S	DO45527	LUSC	ICGC	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.1667
p.M416T	TCGA-AG-3891	READ	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.2222
p.R1679W	TCGA-AJ-A2QO	UCEC	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.1389
p.R419C	TCGA-DU-6392	LGG	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.1389
p.R419C	TCGA-EO-A22R	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.1389
p.W1667C	TCGA-EE-A17Z	SKCM	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation altering degron motif	0.5889
p.G1664C	TCGA-ER-A2NH	SKCM	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.3056
p.R419H	TCGA-EY-A548	UCEC	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.1389
p.R419H	TCGA-FG-6688	LGG	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.1389
p.T1662I	TCGA-FW-A3R5	SKCM	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.25
p.R1663T	TCGA-G2-A2EJ	BLCA	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.2778
p.G422R	TCGA-GN-A26A	SKCM	TCGA	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.0556
p.G1666S	TCGA-RG-A7D4	LIHC	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation altering degron motif	0.5882
p.L1659S	TCGA-XY-A8S2	TGCT	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.1667
p.A408T	DO230326	COCA	ICGC	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation altering degron motif	0.7139
p.V407A	DO222884	COCA	ICGC	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.3056
p.R1662L	DO50817	LIRI	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.25
p.Y422S	DO219881	SKCA	ICGC	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.0556
p.D416Y	DO37896	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.2222
p.V400A	DO47274	SKCM	ICGC	YKENY	DEG_APCC_KENBOX_2	408:412	Mutation rewiring degron network	0.1111
p.E1665G	DO47436	SKCM	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation altering degron motif	0.7199
p.G1659R	DO48665	SKCM	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.1667
p.A1681T	DO41644	UCEC	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.0833
p.R1663G	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.2778
p.R1663G	ACH-000305	Esophageal Cancer	CCLE	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.2778
p.R1663G	EC-GI-10	oesophagus	COSMIC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.2778
p.R1680Q	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.1111
p.R1680Q	ACH-000744	Lung Cancer	CCLE	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.1111
p.R1663S	SIDM00490	Glioma	GDSC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.2778
p.R1663S	ACH-001016	Brain Cancer	CCLE	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.2778
p.R1663S	Becker	central nervous system	COSMIC	VGWTPPGS	DEG_SCF_FBW7_1	1665:1672	Mutation rewiring degron network	0.2778

Kaplan plot for NRAP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRAP

UniProt ID: Q86VF7

Entrez ID: 4892

Protein name: Nebulin-related-anchoring protein (N-RAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRAP in