DegronMD

Uniprot ID: Q86VF7

Source protein: Nebulin-related-anchoring protein

Source gene: NRAP

Class: DEG_SCF_FBW7_1

Location: 1665:1672

E3 ligase: FBXW7

DEGRON score: 0.7719

ASA_SCORE: 35.875

COIL: 0.8189

CONS_SCORE: 0.6772

DSS_SCORE: 0.3567

HELIX: 0.0215

FCONS_SCORE: 1.0208

RIG_SCORE: 0.7094

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1670A	TCGA-17-Z001	LUAD	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.6392
p.R1679W	TCGA-AJ-A2QO	UCEC	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.1389
p.W1667C	TCGA-EE-A17Z	SKCM	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.5889
p.G1664C	TCGA-ER-A2NH	SKCM	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.3056
p.T1662I	TCGA-FW-A3R5	SKCM	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.25
p.R1663T	TCGA-G2-A2EJ	BLCA	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.2778
p.G1666S	TCGA-RG-A7D4	LIHC	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.5882
p.L1659S	TCGA-XY-A8S2	TGCT	TCGA	VGWTPPGS	DEG_SCF_FBW7_1	0.1667
p.R1662L	DO50817	LIRI	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	0.25
p.E1665G	DO47436	SKCM	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	0.7199
p.G1659R	DO48665	SKCM	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	0.1667
p.A1681T	DO41644	UCEC	ICGC	VGWTPPGS	DEG_SCF_FBW7_1	0.0833
p.R1663G	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	VGWTPPGS	DEG_SCF_FBW7_1	0.2778
p.R1663G	ACH-000305	Esophageal Cancer	CCLE	VGWTPPGS	DEG_SCF_FBW7_1	0.2778
p.R1663G	EC-GI-10	oesophagus	COSMIC	VGWTPPGS	DEG_SCF_FBW7_1	0.2778
p.R1680Q	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VGWTPPGS	DEG_SCF_FBW7_1	0.1111
p.R1680Q	ACH-000744	Lung Cancer	CCLE	VGWTPPGS	DEG_SCF_FBW7_1	0.1111
p.R1663S	SIDM00490	Glioma	GDSC	VGWTPPGS	DEG_SCF_FBW7_1	0.2778
p.R1663S	ACH-001016	Brain Cancer	CCLE	VGWTPPGS	DEG_SCF_FBW7_1	0.2778
p.R1663S	Becker	central_nervous_system	COSMIC	VGWTPPGS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VF7	Nebulin-related-anchoring protein	DEG_SCF_FBW7_1	1665:1672	VGWTPPGS	FBXW7	0.7719	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons