Degron: NKAKGKYTFSP
Nebulin
NEB
4429:4439
CBL
0.8795
66.9455
0.7219
0.5861
0.3798
0.1732
1.01
0.7251
Degron related mutations and impact score
| Mutation |
Sample |
Cancer |
Dataset |
Degron |
Degron class |
Impact score |
| p.E4426D | DO8842 | COAD | ICGC | NKAKGKYTFSP | CBL_PTK | 0.25 |
| p.P4442Q | DO228952 | LICA | ICGC | NKAKGKYTFSP | CBL_PTK | 0.25 |
| p.Y4424H | DO231713 | LINC | ICGC | NKAKGKYTFSP | CBL_PTK | 0.1944 |
| p.Y4424H | DO40884 | UCEC | ICGC | NKAKGKYTFSP | CBL_PTK | 0.1944 |
| p.E4426K | DO37831 | SKCM | ICGC | NKAKGKYTFSP | CBL_PTK | 0.25 |
| p.K4432R | ES4 | bone | COSMIC | NKAKGKYTFSP | CBL_PTK | 0.6126 |
| p.D4449Y | SNU-81 | large_intestine | COSMIC | NKAKGKYTFSP | CBL_PTK | 0.0556 |
| p.Y4435S | HCC2998 | large_intestine | COSMIC | NKAKGKYTFSP | CBL_PTK | 0.712 |
| p.S4438L | MZ7-mel | skin | COSMIC | NKAKGKYTFSP | CBL_PTK | 0.6556 |
Drug responses associated with NEB mutations
| Sample |
Cancer |
Mutation (In Degron?) |
Dataset |
Drug |
IC50 |
All proteins holding degron of NKAKGKYTFSP
| Uniprot ID |
Source protein |
Degron class |
Location |
Hit |
E3 ligase |
Degron score |
Detail |
| P20929 | Nebulin | CBL_PTK | 4429:4439 | NKAKGKYTFSP | CBL | 0.8795 | More... |
