DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: DEG_SCF_FBW7_2

Location: 6288:6295

E3 ligase: FBXW7

DEGRON score: 0.9658

ASA_SCORE: 64.425

COIL: 0.4759

CONS_SCORE: 0.4767

DSS_SCORE: 0.5711

HELIX: 0.5008

FCONS_SCORE: 1.096

RIG_SCORE: 0.7666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R6289Q	TCGA-AG-A002	READ	TCGA	LAVTPEME	DEG_SCF_FBW7_2	0.7329
p.R6289Q	TCGA-B5-A0K9	UCEC	TCGA	LAVTPEME	DEG_SCF_FBW7_2	0.7329
p.R6289Q	SIDM01274	Esophageal Carcinoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	0.7329
p.D6302Y	TCGA-EO-A22U	UCEC	TCGA	LAVTPEME	DEG_SCF_FBW7_2	0.1389
p.N6290H	TCGA-EO-A3B0	UCEC	TCGA	LAVTPEME	DEG_SCF_FBW7_2	0.7423
p.N6290H	DO219773	UCEC	ICGC	LAVTPEME	DEG_SCF_FBW7_2	0.7423
p.A6291T	DO228338	MALY	ICGC	LAVTPEME	DEG_SCF_FBW7_2	0.7139
p.A6291T	SIDM00948	Burkitt's Lymphoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	0.7139
p.A6291T	ACH-002232	Lymphoma	CCLE	LAVTPEME	DEG_SCF_FBW7_2	0.7139
p.A6291T	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LAVTPEME	DEG_SCF_FBW7_2	0.7139
p.E6295K	DO223286	UCEC	ICGC	LAVTPEME	DEG_SCF_FBW7_2	0.7022
p.R6287C	SIDM02077	Colorectal Carcinoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	0.3056
p.V6288I	SIDM00799	Glioblastoma	GDSC	LAVTPEME	DEG_SCF_FBW7_2	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20929	Nebulin	DEG_SCF_FBW7_2	6288:6295	LAVTPEME	FBXW7	0.9658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons