DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: DEG_APCC_KENBOX_2

Location: 6278:6282

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8593

ASA_SCORE: 90.3

COIL: 0.4348

CONS_SCORE: 0.4556

DSS_SCORE: 0.4774

HELIX: 0.4874

FCONS_SCORE: 1.0379

RIG_SCORE: 0.7314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W6276G	TCGA-53-7624	LUAD	TCGA	YKENM	DEG_APCC_KENBOX_2	0.2778
p.Q6275K	TCGA-AB-2871	LAML	TCGA	YKENM	DEG_APCC_KENBOX_2	0.25
p.E6281K	TCGA-EB-A4IS	SKCM	TCGA	YKENM	DEG_APCC_KENBOX_2	0.7022
p.E6281K	DO47281	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	0.7022
p.R6270Q	TCGA-EO-A22R	UCEC	TCGA	YKENM	DEG_APCC_KENBOX_2	0.1111
p.Y6272H	TCGA-F7-A624	HNSC	TCGA	YKENM	DEG_APCC_KENBOX_2	0.1667
p.Y6272H	DO44440	HNSC	ICGC	YKENM	DEG_APCC_KENBOX_2	0.1667
p.E6280Q	DO219007	BLCA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.6744
p.Y6278F	DO231940	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.7528
p.R6268S	DO231951	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.0556
p.S6274R	DO229038	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.2222
p.K6279R	DO52021	LUSC	ICGC	YKENM	DEG_APCC_KENBOX_2	0.7237
p.R6268H	DO48889	PBCA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.0556
p.E6280V	DO37831	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	0.7693
p.S6275L	DO42793	UCEC	ICGC	YKENM	DEG_APCC_KENBOX_2	0.25
p.R6287C	SIDM02077	Colorectal Carcinoma	GDSC	YKENM	DEG_APCC_KENBOX_2	0.1944
p.N6272K	HCC70	breast	COSMIC	YKENM	DEG_APCC_KENBOX_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons