DegronMD

Uniprot ID: P20929

Source protein: Nebulin

Source gene: NEB

Class: DEG_APCC_KENBOX_2

Location: 6371:6375

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5332

ASA_SCORE: 89

COIL: 0.5334

CONS_SCORE: 0.3909

DSS_SCORE: 0.5722

HELIX: 0.341

FCONS_SCORE: 0.9791

RIG_SCORE: 0.7412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E6372V	TCGA-AX-A0J0	UCEC	TCGA	YKENM	DEG_APCC_KENBOX_2	0.7693
p.Y6374H	TCGA-BS-A0UF	UCEC	TCGA	YKENM	DEG_APCC_KENBOX_2	0.7229
p.N6373S	TCGA-CA-6717	COAD	TCGA	YKENM	DEG_APCC_KENBOX_2	0.7069
p.N6373S	DO8264	COAD	ICGC	YKENM	DEG_APCC_KENBOX_2	0.7069
p.E6372K	TCGA-EE-A3J5	SKCM	TCGA	YKENM	DEG_APCC_KENBOX_2	0.7022
p.S6361N	DO228306	BRCA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.0556
p.N6373K	DO233170	GACA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.6918
p.N6373Y	DO228203	LICA	ICGC	YKENM	DEG_APCC_KENBOX_2	0.7059
p.P6380Q	DO23774	LUAD	ICGC	YKENM	DEG_APCC_KENBOX_2	0.1944
p.P6380Q	DO47578	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	0.1944
p.P6382H	DO37487	SKCM	ICGC	YKENM	DEG_APCC_KENBOX_2	0.1389
p.E6372G	SIDM00193	Colorectal Carcinoma	GDSC	YKENM	DEG_APCC_KENBOX_2	0.7199
p.E6372G	ACH-000991	Colon/Colorectal Cancer	CCLE	YKENM	DEG_APCC_KENBOX_2	0.7199
p.E6372G	SNU-81	large_intestine	COSMIC	YKENM	DEG_APCC_KENBOX_2	0.7199
p.P6380L	SNU-1040	large_intestine	COSMIC	YKENM	DEG_APCC_KENBOX_2	0.1944
p.V6369I	MDA-MB-231	breast	COSMIC	YKENM	DEG_APCC_KENBOX_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons