DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 5314:5322

E3 ligase: COP1

DEGRON score: 0.9942

ASA_SCORE: 66.3556

COIL: 0.696

CONS_SCORE: 0.406

DSS_SCORE: 0.4539

HELIX: 0.05

FCONS_SCORE: 0.9929

RIG_SCORE: 0.7133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L5331I	TCGA-AX-A06F	UCEC	TCGA	DLDASVPSM	DEG_COP1_1	0.0833
p.L5331I	DO41752	UCEC	ICGC	DLDASVPSM	DEG_COP1_1	0.0833
p.L5304V	TCGA-FD-A43N	BLCA	TCGA	DLDASVPSM	DEG_COP1_1	0.0556
p.L5304V	DO502	BLCA	ICGC	DLDASVPSM	DEG_COP1_1	0.0556
p.L5306W	TCGA-G3-AAV4	LIHC	TCGA	DLDASVPSM	DEG_COP1_1	0.1111
p.L5306W	DO52298	LIHC	ICGC	DLDASVPSM	DEG_COP1_1	0.1111
p.S5321N	DO48436	BLCA	ICGC	DLDASVPSM	DEG_COP1_1	0.818
p.S5318T	DO233703	GACA	ICGC	DLDASVPSM	DEG_COP1_1	0.7116
p.L5329F	DO45209	LIRI	ICGC	DLDASVPSM	DEG_COP1_1	0.1389
p.K5307E	DO230530	LUSC	ICGC	DLDASVPSM	DEG_COP1_1	0.5833
p.P5320S	DO222420	MELA	ICGC	DLDASVPSM	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	5314:5322	DLDASVPSM	COP1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons