DegronMD - Q09666(AHNAK)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M699V	TCGA-06-5416	GBM	TCGA	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.3056
p.M699V	DO10880	GBM	ICGC	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.3056
p.V5000L	TCGA-06-5856	GBM	TCGA	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.6765
p.V5000L	DO13456	GBM	ICGC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.6765
p.T190A	TCGA-28-1751	GBM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.7139
p.T190A	DO13743	GBM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.7139
p.D4962Y	TCGA-2W-A8YY	CESC	TCGA	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.25
p.D4962Y	DO223732	CESC	ICGC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.25
p.L3907V	TCGA-34-8454	LUSC	TCGA	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation altering degron motif	0.5654
p.L3907V	DO50094	LUSC	ICGC	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation altering degron motif	0.5654
p.L3907V	SIDM00210	Ovarian Carcinoma	GDSC	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation altering degron motif	0.5654
p.L3907V	SIDM01147	Gastric Carcinoma	GDSC	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation altering degron motif	0.5654
p.E853Q	TCGA-37-A5EL	LUSC	TCGA	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.3056
p.E853Q	DO223718	LUSC	ICGC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.3056
p.T553I	TCGA-46-6025	LUSC	TCGA	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation blocking phosphorylation signal	0.6667
p.T553I	DO26644	LUSC	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation blocking phosphorylation signal	0.6667
p.K2013N	TCGA-55-6969	LUAD	TCGA	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.2778
p.K2013N	DO24586	LUAD	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.2778
p.T5796M	TCGA-55-A490	LUAD	TCGA	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.7423
p.T5796M	DO24596	LUAD	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.7423
p.T5796M	SIDM00444	Esophageal Carcinoma	GDSC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.7423
p.P1090S	TCGA-67-3772	LUAD	TCGA	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.25
p.P1090S	DO23729	LUAD	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.25
p.D3119N	TCGA-75-7027	LUAD	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6932
p.D3119N	DO24811	LUAD	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6932
p.A2165V	TCGA-83-5908	LUAD	TCGA	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.1389
p.A2165V	DO23572	LUAD	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.1389
p.D1109H	TCGA-94-7943	LUSC	TCGA	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.1111
p.D1109H	DO26475	LUSC	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.1111
p.I1359M	TCGA-94-8491	LUSC	TCGA	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.2778
p.I1359M	DO219174	LUSC	ICGC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.2778
p.K1363R	TCGA-A1-A0SK	BRCA	TCGA	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation blocking ubiquitination signal	0.6111
p.K1363R	DO4143	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation blocking ubiquitination signal	0.6111
p.D1340H	TCGA-A2-A0YK	BRCA	TCGA	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.0833
p.D1340H	DO2836	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.0833
p.P2223L	TCGA-A5-A0G2	UCEC	TCGA	EGEMKVPDV	DEG_COP1_1	2210:2218	Mutation rewiring degron network	0.1944
p.P2223L	DO41235	UCEC	ICGC	EGEMKVPDV	DEG_COP1_1	2210:2218	Mutation rewiring degron network	0.1944
p.A1801V	TCGA-A5-A0G2	UCEC	TCGA	EIDASVPEL	DEG_COP1_1	1798:1806	Mutation altering degron motif	0.5825
p.A1801V	DO41235	UCEC	ICGC	EIDASVPEL	DEG_COP1_1	1798:1806	Mutation altering degron motif	0.5825
p.D684N	TCGA-A5-A0G2	UCEC	TCGA	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1111
p.D684N	TCGA-AX-A0J0	UCEC	TCGA	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1111
p.D684N	TCGA-F5-6814	READ	TCGA	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1111
p.D684N	DO36556	READ	ICGC	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1111
p.D684N	DO41235	UCEC	ICGC	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1111
p.D684N	DO41133	UCEC	ICGC	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1111
p.E549D	TCGA-A5-A1OF	UCEC	TCGA	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation altering degron motif	0.6758
p.E549D	DO42568	UCEC	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation altering degron motif	0.6758
p.D2164H	TCGA-AC-A23H	BRCA	TCGA	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.1667
p.D2164H	DO2401	BRCA	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.1667
p.D2145E	TCGA-AG-3892	READ	TCGA	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.1944
p.D2145E	DO36394	READ	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.1944
p.N547S	TCGA-AO-A128	BRCA	TCGA	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation altering degron motif	0.5958
p.N547S	DO5326	BRCA	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation altering degron motif	0.5958
p.T5798M	TCGA-AP-A1DK	UCEC	TCGA	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.8534
p.T5798M	DO8858	COAD	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.8534
p.T5798M	DO42033	UCEC	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.8534
p.N5006D	TCGA-AP-A1DK	UCEC	TCGA	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation rewiring degron network	0.25
p.N5006D	TCGA-AP-A1DK	UCEC	TCGA	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation rewiring degron network	0.3056
p.N5006D	DO42033	UCEC	ICGC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation rewiring degron network	0.25
p.N5006D	DO42033	UCEC	ICGC	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation rewiring degron network	0.3056
p.V3898G	TCGA-AP-A1DV	UCEC	TCGA	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation rewiring degron network	0.3056
p.V3898G	DO43186	UCEC	ICGC	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation rewiring degron network	0.3056
p.L5331I	TCGA-AX-A06F	UCEC	TCGA	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation rewiring degron network	0.0833
p.L5331I	DO41752	UCEC	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation rewiring degron network	0.0833
p.I3134V	TCGA-AX-A06F	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.0833
p.I3134V	DO41752	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.0833
p.I3134V	SIDM00333	Endometrial Carcinoma	GDSC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.0833
p.I3134V	ACH-000988	Endometrial/Uterine Cancer	CCLE	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.0833
p.I3134V	MFE-319	endometrium	COSMIC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.0833
p.E4950Q	TCGA-B5-A11R	UCEC	TCGA	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.2222
p.E4950Q	DO43787	UCEC	ICGC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.2222
p.D703Y	TCGA-B5-A1MR	UCEC	TCGA	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1944
p.D703Y	DO41758	UCEC	ICGC	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation rewiring degron network	0.1944
p.V3125M	TCGA-B5-A1MW	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6097
p.V3125M	TCGA-BA-A6DF	HNSC	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6097
p.V3125M	DO44442	HNSC	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6097
p.V3125M	DO42913	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6097
p.A4989G	TCGA-BA-4077	HNSC	TCGA	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation rewiring degron network	0.1667
p.A4989G	DO15647	HNSC	ICGC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation rewiring degron network	0.1667
p.E5008Q	TCGA-BA-5152	HNSC	TCGA	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation altering degron motif	0.5633
p.E5008Q	DO14393	HNSC	ICGC	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation altering degron motif	0.5633
p.I1103T	TCGA-BR-7723	STAD	TCGA	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.2778
p.I1103T	DO38875	STAD	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.2778
p.D4959G	TCGA-CA-6717	COAD	TCGA	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation altering degron motif	0.7198
p.D4959G	DO8264	COAD	ICGC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation altering degron motif	0.7198
p.K3115E	TCGA-CA-6717	COAD	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.2778
p.K3115E	DO8264	COAD	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.2778
p.S1088C	TCGA-CG-4440	STAD	TCGA	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation blocking phosphorylation signal	0.6389
p.S1088C	DO38855	STAD	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation blocking phosphorylation signal	0.6389
p.M3120I	TCGA-CQ-6221	HNSC	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6507
p.M3120I	TCGA-ZD-A8I3	CHOL	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6507
p.M3120I	DO14622	HNSC	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6507
p.D1342Y	TCGA-CV-7248	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.1389
p.D1342Y	DO14806	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.1389
p.M2487I	TCGA-CV-7427	HNSC	TCGA	DVDVSVPEV	DEG_COP1_1	2470:2478	Mutation rewiring degron network	0.0833
p.M2487I	TCGA-DK-A3WW	BLCA	TCGA	DVDVSVPEV	DEG_COP1_1	2470:2478	Mutation rewiring degron network	0.0833
p.M2487I	DO481	BLCA	ICGC	DVDVSVPEV	DEG_COP1_1	2470:2478	Mutation rewiring degron network	0.0833
p.M2487I	DO14286	HNSC	ICGC	DVDVSVPEV	DEG_COP1_1	2470:2478	Mutation rewiring degron network	0.0833
p.D1686H	TCGA-CV-7427	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.7688
p.D1686H	DO14286	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.7688
p.E1230Q	TCGA-CV-7427	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation rewiring degron network	0.3056
p.E1230Q	DO14286	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation rewiring degron network	0.3056
p.P3123S	TCGA-D3-A3ML	SKCM	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6752
p.P3123S	DO47413	SKCM	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6752
p.P2149H	TCGA-D5-6928	COAD	TCGA	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.3056
p.P2149H	DO7776	COAD	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.3056
p.G1233E	TCGA-D8-A27L	BRCA	TCGA	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation rewiring degron network	0.2222
p.G1233E	DO2180	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation rewiring degron network	0.2222
p.M1224I	TCGA-D9-A6EC	SKCM	TCGA	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.6507
p.M1224I	DO50291	SKCM	ICGC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.6507
p.L557I	TCGA-DU-6392	LGG	TCGA	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation rewiring degron network	0.1111
p.L557I	DO22237	LGG	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation rewiring degron network	0.1111
p.D1228E	TCGA-DX-A8BP	SARC	TCGA	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.5647
p.D1228E	DO220056	SARC	ICGC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.5647
p.P1227T	TCGA-E6-A1LX	UCEC	TCGA	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7031
p.P1227T	DO41020	UCEC	ICGC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7031
p.K855E	TCGA-EB-A6QZ	SKCM	TCGA	ESEIKVPDV	DEG_COP1_1	844:852	Mutation blocking ubiquitination signal	0.6944
p.K855E	DO48626	SKCM	ICGC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation blocking ubiquitination signal	0.6944
p.V3125L	TCGA-EC-A1NJ	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.5654
p.V3125L	DO40855	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.5654
p.V3125L	ACH-000261	Lung Cancer	CCLE	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.5654
p.P185Q	TCGA-EE-A181	SKCM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.5924
p.P185Q	DO37444	SKCM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.5924
p.S5782L	TCGA-EE-A29E	SKCM	TCGA	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation blocking phosphorylation signal	0.5
p.S5782L	DO37831	SKCM	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation blocking phosphorylation signal	0.5
p.S2150I	TCGA-EM-A4FQ	THCA	TCGA	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation altering degron motif	0.8453
p.S2150I	DO48119	THCA	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation altering degron motif	0.8453
p.D2022Y	TCGA-EO-A22R	UCEC	TCGA	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation altering degron motif	0.7325
p.D2022Y	DO42713	UCEC	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation altering degron motif	0.7325
p.L5304V	TCGA-FD-A43N	BLCA	TCGA	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation rewiring degron network	0.0556
p.L5304V	DO502	BLCA	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation rewiring degron network	0.0556
p.Q200K	TCGA-FS-A1ZG	SKCM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.1389
p.Q200K	DO37523	SKCM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.1389
p.E179D	TCGA-FS-A1ZZ	SKCM	TCGA	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.1667
p.E179D	DO37412	SKCM	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.1667
p.L5306W	TCGA-G3-AAV4	LIHC	TCGA	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation rewiring degron network	0.1111
p.L5306W	DO52298	LIHC	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation rewiring degron network	0.1111
p.P2028L	TCGA-IB-7651	PAAD	TCGA	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.1944
p.P2028L	DO46657	PAAD	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.1944
p.I4963V	TCGA-IQ-A6SG	HNSC	TCGA	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.2222
p.I4963V	DO223267	HNSC	ICGC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.2222
p.D3892N	TCGA-LN-A49S	ESCA	TCGA	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation rewiring degron network	0.1389
p.D1109N	TCGA-MV-A51V	BLCA	TCGA	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.1111
p.D1109N	DO474	BLCA	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.1111
p.V1673L	TCGA-NK-A5CX	LUSC	TCGA	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation rewiring degron network	0.1667
p.V1673L	DO219211	LUSC	ICGC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation rewiring degron network	0.1667
p.I3134M	TCGA-QS-A5YQ	UCEC	TCGA	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.0833
p.I3134M	DO49073	UCEC	ICGC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation rewiring degron network	0.0833
p.L548P	TCGA-RD-A8N1	STAD	TCGA	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation altering degron motif	0.6471
p.L548P	DO50136	STAD	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation altering degron motif	0.6471
p.S1674P	TCGA-S9-A7IS	LGG	TCGA	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation blocking phosphorylation signal	0.6389
p.S1674P	DO48606	LGG	ICGC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation blocking phosphorylation signal	0.6389
p.A857T	TCGA-SW-A7EA	STAD	TCGA	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.1944
p.A857T	DO51749	STAD	ICGC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.1944
p.L1345F	TCGA-UF-A7JT	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.2222
p.L1345F	DO219090	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.2222
p.E5008K	TCGA-VQ-A8P5	STAD	TCGA	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation altering degron motif	0.591
p.E5008K	DO51763	STAD	ICGC	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation altering degron motif	0.591
p.I697F	TCGA-W5-AA39	CHOL	TCGA	VKTPKIS	DEG_SCF_FBW7_1	692:698	Mutation altering degron motif	0.6304
p.I2025M	TCGA-XF-A8HE	BLCA	TCGA	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.2778
p.I2025M	DO49797	BLCA	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.2778
p.G5804W	TCGA-XF-A9T8	BLCA	TCGA	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation rewiring degron network	0.1667
p.G5804W	DO51927	BLCA	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation rewiring degron network	0.1667
p.E5002K	TCGA-XF-A9T8	BLCA	TCGA	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7022
p.E5002K	DO51927	BLCA	ICGC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7022
p.S5321N	DO48436	BLCA	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation altering degron motif	0.818
p.V1220I	DO225358	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation rewiring degron network	0.3056
p.E2015Q	DO224700	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation altering degron motif	0.6744
p.D1686Y	DO222421	BTCA	ICGC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.7325
p.V838I	DO223504	CLLE	ICGC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.1667
p.M4958T	DO227844	COCA	ICGC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation altering degron motif	0.6312
p.M4958T	DO233624	GACA	ICGC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation altering degron motif	0.6312
p.M3891V	DO222737	COCA	ICGC	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation rewiring degron network	0.1111
p.K2141T	DO222884	COCA	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation substituting flanking lysine	0.1944
p.V2023A	DO52450	COCA	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation altering degron motif	0.5825
p.D1102G	DO234459	ESAD	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.3056
p.G5016S	DO223014	ESCA	ICGC	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation rewiring degron network	0.25
p.G5016S	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation rewiring degron network	0.25
p.G5016S	ACH-000447	Lung Cancer	CCLE	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation rewiring degron network	0.25
p.G5016S	NCI-H2228	lung	COSMIC	LETPEIS	DEG_SCF_FBW7_1	5007:5013	Mutation rewiring degron network	0.25
p.P1813L	DO233254	GACA	ICGC	EIDASVPEL	DEG_COP1_1	1798:1806	Mutation rewiring degron network	0.1389
p.S5318T	DO233703	GACA	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation altering degron motif	0.7116
p.I543T	DO233843	GACA	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation altering degron motif	0.7078
p.K842T	DO233921	GACA	ICGC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.2778
p.D1109V	DO229505	LAML	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.1111
p.V1098F	DO230659	LAML	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	DO231140	LAML	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	DO229038	LICA	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	DO229047	LICA	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00570	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00614	Hepatocellular Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01197	Colorectal Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00565	Oral Cavity Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00544	Neuroblastoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01145	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00417	Plasma Cell Myeloma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00526	Chronic Myelogenous Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00502	B-Lymphoblastic Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00280	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00807	Bladder Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00217	Colorectal Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00996	Thyroid Gland Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00233	T-Lymphoblastic Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00591	Oral Cavity Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01372	Pancreatic Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01612	Endometrial Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM00168	Head and Neck Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01393	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01472	Hepatocellular Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01347	Ovarian Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01442	Glioma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.V1098F	SIDM01343	Gastric Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7068
p.D542E	DO229019	LICA	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation rewiring degron network	0.3056
p.A1801D	DO229027	LICA	ICGC	EIDASVPEL	DEG_COP1_1	1798:1806	Mutation altering degron motif	0.6682
p.P2156T	DO229026	LICA	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation altering degron motif	0.7031
p.P1090Q	DO229031	LICA	ICGC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.25
p.L3895M	DO229038	LICA	ICGC	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation rewiring degron network	0.2222
p.V1213M	DO229052	LICA	ICGC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation rewiring degron network	0.1111
p.G2005E	DO50970	LICA	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.0556
p.K537R	DO23232	LINC	ICGC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation blocking ubiquitination signal	0.6111
p.L5329F	DO45209	LIRI	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation rewiring degron network	0.1389
p.D3890G	DO23516	LIRI	ICGC	EGDMQVPDL	DEG_COP1_1	3899:3907	Mutation rewiring degron network	0.0833
p.K5307E	DO230530	LUSC	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation blocking ubiquitination signal	0.5833
p.E1679G	DO27809	MALY	ICGC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.7199
p.D2203Y	DO52694	MALY	ICGC	EGEMKVPDV	DEG_COP1_1	2210:2218	Mutation rewiring degron network	0.1389
p.S1344F	DO220893	MELA	ICGC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation blocking phosphorylation signal	0.6389
p.R1811K	DO220902	MELA	ICGC	EIDASVPEL	DEG_COP1_1	1798:1806	Mutation rewiring degron network	0.1944
p.M2018I	DO222363	MELA	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation altering degron motif	0.6507
p.P5320S	DO222420	MELA	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation altering degron motif	0.6752
p.G202W	DO231584	NBL	ICGC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.0833
p.D837Y	DO36556	READ	ICGC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.1389
p.D1697V	DO46819	RECA	ICGC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation rewiring degron network	0.0556
p.M2030I	DO218872	SKCA	ICGC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.1389
p.L854I	SIDM00683	Prostate Carcinoma	GDSC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.2778
p.L854I	ACH-000977	lymph node	CCLE	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.2778
p.V1687I	SIDM00216	Colorectal Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.5965
p.V1687I	ACH-000989	Colon/Colorectal Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.5965
p.V1687I	SNU-175	large intestine	COSMIC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.5965
p.V1098I	SIDM00371	Pancreatic Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7076
p.V1098I	SUIT-2	pancreas	COSMIC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.7076
p.P1090L	SIDM00403	T-Lymphoblastic Leukemia	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.25
p.P1090L	ACH-000636	Leukemia	CCLE	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.25
p.P1090L	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.25
p.G1083R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.0556
p.G1083R	SIDM00855	Other Sarcomas	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.0556
p.G1083R	ACH-000375	Kidney Cancer	CCLE	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.0556
p.G1083R	ACH-000789	Lung Cancer	CCLE	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.0556
p.G1083R	G-402	soft tissue	COSMIC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.0556
p.G1083R	NCI-H810	lung	COSMIC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.0556
p.I182V	SIDM01126	Small Cell Lung Carcinoma	GDSC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.25
p.I182V	ACH-001599	Lung Cancer	CCLE	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.25
p.I182V	NCI-H64	lung	COSMIC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.25
p.D2164V	SIDM00594	Acute Myeloid Leukemia	GDSC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation rewiring degron network	0.1667
p.H187Y	SIDM00789	Colorectal Carcinoma	GDSC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.6118
p.H187Y	ACH-000997	Colon/Colorectal Cancer	CCLE	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.6118
p.H187Y	HCT-15	large intestine	COSMIC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.6118
p.G2222W	SIDM00945	Colorectal Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	2210:2218	Mutation rewiring degron network	0.2222
p.G2222W	CL-34	large intestine	COSMIC	EGEMKVPDV	DEG_COP1_1	2210:2218	Mutation rewiring degron network	0.2222
p.M3120T	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	EGDMKVPDV	DEG_COP1_1	3117:3125	Mutation altering degron motif	0.6312
p.D1340V	SIDM00481	Ovarian Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.0833
p.D1340V	ACH-000116	Ovarian Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.0833
p.D1340V	OAW-28	ovary	COSMIC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.0833
p.E1221A	SIDM00260	Gastric Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	SIDM00248	Gastric Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	ACH-000758	Gastric Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	ACH-002161	Gastric Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	MKN28	stomach	COSMIC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E4966K	SIDM00820	Kidney Carcinoma	GDSC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.1389
p.E4966K	ACH-002188	Kidney Cancer	CCLE	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.1389
p.E4966K	RCC-ER	kidney	COSMIC	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.1389
p.G1105S	SIDM00282	Colorectal Carcinoma	GDSC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.2222
p.G1105S	ACH-000998	Colon/Colorectal Cancer	CCLE	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.2222
p.G1105S	CW-2	large intestine	COSMIC	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation rewiring degron network	0.2222
p.G2027V	SIDM00965	Small Cell Lung Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.2222
p.G2027V	ACH-000800	Lung Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.2222
p.G2027V	NCI-H446	lung	COSMIC	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation rewiring degron network	0.2222
p.D1228H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7688
p.D1228H	H513	pleura	COSMIC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7688
p.P5001L	SIDM00006	Other Solid Cancers	GDSC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7582
p.P5001L	ACH-001552	Skin Cancer	CCLE	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7582
p.P5001L	MCC26	skin	COSMIC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7582
p.P5001S	SIDM00006	Other Solid Cancers	GDSC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.6752
p.P5001S	ACH-001552	Skin Cancer	CCLE	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.6752
p.P5001S	MCC26	skin	COSMIC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.6752
p.V4998A	SIDM00217	Colorectal Carcinoma	GDSC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.5825
p.V4998A	ACH-000999	Colon/Colorectal Cancer	CCLE	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.5825
p.V4998A	SNU-1040	large intestine	COSMIC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.5825
p.D1670N	SIDM00150	Colorectal Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation rewiring degron network	0.0833
p.D1670N	KM12	large intestine	COSMIC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation rewiring degron network	0.0833
p.G5803D	SIDM01739	Small Cell Lung Carcinoma	GDSC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation rewiring degron network	0.1944
p.S5807F	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation blocking phosphorylation signal	0.5278
p.D862E	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ESEIKVPDV	DEG_COP1_1	844:852	Mutation rewiring degron network	0.0556
p.S201F	SIDM01699	Chondrosarcoma	GDSC	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation blocking phosphorylation signal	0.5556
p.S201F	ACH-000224	Non-Cancerous	CCLE	PRHELTEIS	DEG_APCC_DBOX_1	185:193	Mutation blocking phosphorylation signal	0.5556
p.I1359S	SIDM01588	Endometrial Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.2778
p.I1359S	ACH-000993	Endometrial/Uterine Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1349:1357	Mutation rewiring degron network	0.2778
p.E2015K	ACH-000868	Lung Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	2015:2023	Mutation altering degron motif	0.7022
p.R556G	ACH-000919	Gastric Cancer	CCLE	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation rewiring degron network	0.1389
p.R556G	IM-95	stomach	COSMIC	IETPNLE	DEG_SCF_FBW7_2	543:549	Mutation rewiring degron network	0.1389
p.D1100N	ACH-000923	Lymphoma	CCLE	EGEMQVPDV	DEG_COP1_1	1093:1101	Mutation altering degron motif	0.6932
p.I1696T	ACH-000961	Endometrial/Uterine Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation rewiring degron network	0.0833
p.E4966D	ACH-000975	Lung Cancer	CCLE	LDVHMD	LIG_APCC_ABBA_1	4954:4959	Mutation rewiring degron network	0.1389
p.N2461K	ACH-001970	Metastasis	CCLE	DVDVSVPEV	DEG_COP1_1	2470:2478	Mutation rewiring degron network	0.0833
p.E2210K	Sarc9371	bone	COSMIC	EGEMKVPDV	DEG_COP1_1	2210:2218	Mutation altering degron motif	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AHNAK

UniProt ID: Q09666

Entrez ID: 79026

Protein name: Neuroblast differentiation-associated protein AHNAK (Desmoyokin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AHNAK in