DegronMD - Q09666(AHNAK)

FUNCTION: May be required for neuronal cell differentiation.

GO - Biological processes (BP): positive regulation of plasma membrane repair [GO:1905686]; regulation of RNA splicing [GO:0043484]; regulation of voltage-gated calcium channel activity [GO:1901385]

GO - Molecular function (MF): cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; S100 protein binding [GO:0044548]; structural molecule activity conferring elasticity [GO:0097493]

GO - Cellular component (CC): actin cytoskeleton [GO:0015629]; cell-cell contact zone [GO:0044291]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [... View more >>

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PRHELTEIS	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Neuroblast differentiation-associated protein AHNAK	185:193	More..
ESEIKVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	844:852	More..
EGEMQVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	1093:1101	More..
EGEMKVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	1221:1229	More..
EGEMKVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	1349:1357	More..
EGEMKVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	1679:1687	More..
EIDASVPEL	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	1798:1806	More..
EGEMKVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	2015:2023	More..
SVDVEVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	2150:2158	More..
EGEMKVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	2210:2218	More..
DVDVSVPEV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	2470:2478	More..
EGDMKVPDV	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	3117:3125	More..
EGDMQVPDL	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	3899:3907	More..
SLDVTVPEA	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	4995:5003	More..
DLDASVPSM	DEG_COP1_1	COP1	Neuroblast differentiation-associated protein AHNAK	5314:5322	More..
VKTPKIS	DEG_SCF_FBW7_1	FBXW7	Neuroblast differentiation-associated protein AHNAK	692:698	More..
LETPEIS	DEG_SCF_FBW7_1	FBXW7	Neuroblast differentiation-associated protein AHNAK	5007:5013	More..
PSTPTGT	DEG_SCF_FBW7_1	FBXW7	Neuroblast differentiation-associated protein AHNAK	5792:5798	More..
IETPNLE	DEG_SCF_FBW7_2	FBXW7	Neuroblast differentiation-associated protein AHNAK	543:549	More..
LDVHMD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Neuroblast differentiation-associated protein AHNAK	4954:4959	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T5798M	TCGA-AP-A1DK	UCEC	TCGA	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.8534
p.T5798M	DO8858	COAD	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.8534
p.T5798M	DO42033	UCEC	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.8534
p.S2150I	TCGA-EM-A4FQ	THCA	TCGA	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation altering degron motif	0.8453
p.S2150I	DO48119	THCA	ICGC	SVDVEVPDV	DEG_COP1_1	2150:2158	Mutation altering degron motif	0.8453
p.S5321N	DO48436	BLCA	ICGC	DLDASVPSM	DEG_COP1_1	5314:5322	Mutation altering degron motif	0.818
p.E1221A	SIDM00260	Gastric Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	SIDM00248	Gastric Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	ACH-000758	Gastric Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	ACH-002161	Gastric Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.E1221A	MKN28	stomach	COSMIC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7701
p.D1686H	TCGA-CV-7427	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.7688
p.D1686H	DO14286	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	1679:1687	Mutation altering degron motif	0.7688
p.D1228H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7688
p.D1228H	H513	pleura	COSMIC	EGEMKVPDV	DEG_COP1_1	1221:1229	Mutation altering degron motif	0.7688
p.P5001L	SIDM00006	Other Solid Cancers	GDSC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7582
p.P5001L	ACH-001552	Skin Cancer	CCLE	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7582
p.P5001L	MCC26	skin	COSMIC	SLDVTVPEA	DEG_COP1_1	4995:5003	Mutation altering degron motif	0.7582
p.T5796M	TCGA-55-A490	LUAD	TCGA	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.7423
p.T5796M	DO24596	LUAD	ICGC	PSTPTGT	DEG_SCF_FBW7_1	5792:5798	Mutation altering degron motif	0.7423

Showing 1 to 20 of 306 entries

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Kaplan plot for AHNAK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AHNAK

UniProt ID: Q09666

Entrez ID: 79026

Protein name: Neuroblast differentiation-associated protein AHNAK (Desmoyokin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AHNAK in