DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 1221:1229

E3 ligase: COP1

DEGRON score: 0.9542

ASA_SCORE: 81.6556

COIL: 0.5337

CONS_SCORE: 0.5516

DSS_SCORE: 0.4832

HELIX: 0.018

FCONS_SCORE: 1.0754

RIG_SCORE: 0.7602

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1230Q	TCGA-CV-7427	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	0.3056
p.E1230Q	DO14286	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	0.3056
p.G1233E	TCGA-D8-A27L	BRCA	TCGA	EGEMKVPDV	DEG_COP1_1	0.2222
p.G1233E	DO2180	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.2222
p.M1224I	TCGA-D9-A6EC	SKCM	TCGA	EGEMKVPDV	DEG_COP1_1	0.6507
p.M1224I	DO50291	SKCM	ICGC	EGEMKVPDV	DEG_COP1_1	0.6507
p.D1228E	TCGA-DX-A8BP	SARC	TCGA	EGEMKVPDV	DEG_COP1_1	0.5647
p.D1228E	DO220056	SARC	ICGC	EGEMKVPDV	DEG_COP1_1	0.5647
p.P1227T	TCGA-E6-A1LX	UCEC	TCGA	EGEMKVPDV	DEG_COP1_1	0.7031
p.P1227T	DO41020	UCEC	ICGC	EGEMKVPDV	DEG_COP1_1	0.7031
p.V1220I	DO225358	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.3056
p.V1213M	DO229052	LICA	ICGC	EGEMKVPDV	DEG_COP1_1	0.1111
p.E1221A	SIDM00260	Gastric Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.7701
p.E1221A	SIDM00248	Gastric Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.7701
p.E1221A	ACH-000758	Gastric Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.7701
p.E1221A	ACH-002161	Gastric Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.7701
p.E1221A	MKN28	stomach	COSMIC	EGEMKVPDV	DEG_COP1_1	0.7701
p.D1228H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.7688
p.D1228H	H513	pleura	COSMIC	EGEMKVPDV	DEG_COP1_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1221:1229	EGEMKVPDV	COP1	0.9542	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1349:1357	EGEMKVPDV	COP1	0.9174	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1679:1687	EGEMKVPDV	COP1	0.8823	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2015:2023	EGEMKVPDV	COP1	0.8467	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2210:2218	EGEMKVPDV	COP1	0.8923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons