DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 1679:1687

E3 ligase: COP1

DEGRON score: 0.8823

ASA_SCORE: 77.9778

COIL: 0.4383

CONS_SCORE: 0.5126

DSS_SCORE: 0.4938

HELIX: 0.0129

FCONS_SCORE: 1.0136

RIG_SCORE: 0.748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1686H	TCGA-CV-7427	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	0.7688
p.D1686H	DO14286	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	0.7688
p.V1673L	TCGA-NK-A5CX	LUSC	TCGA	EGEMKVPDV	DEG_COP1_1	0.1667
p.V1673L	DO219211	LUSC	ICGC	EGEMKVPDV	DEG_COP1_1	0.1667
p.S1674P	TCGA-S9-A7IS	LGG	TCGA	EGEMKVPDV	DEG_COP1_1	0.6389
p.S1674P	DO48606	LGG	ICGC	EGEMKVPDV	DEG_COP1_1	0.6389
p.D1686Y	DO222421	BTCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.7325
p.E1679G	DO27809	MALY	ICGC	EGEMKVPDV	DEG_COP1_1	0.7199
p.D1697V	DO46819	RECA	ICGC	EGEMKVPDV	DEG_COP1_1	0.0556
p.V1687I	SIDM00216	Colorectal Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.5965
p.V1687I	ACH-000989	Colon/Colorectal Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.5965
p.V1687I	SNU-175	large_intestine	COSMIC	EGEMKVPDV	DEG_COP1_1	0.5965
p.D1670N	SIDM00150	Colorectal Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.0833
p.D1670N	KM12	large_intestine	COSMIC	EGEMKVPDV	DEG_COP1_1	0.0833
p.I1696T	ACH-000961	Endometrial/Uterine Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1221:1229	EGEMKVPDV	COP1	0.9542	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1349:1357	EGEMKVPDV	COP1	0.9174	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1679:1687	EGEMKVPDV	COP1	0.8823	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2015:2023	EGEMKVPDV	COP1	0.8467	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2210:2218	EGEMKVPDV	COP1	0.8923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons