DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 1349:1357

E3 ligase: COP1

DEGRON score: 0.9174

ASA_SCORE: 80.7

COIL: 0.4891

CONS_SCORE: 0.4371

DSS_SCORE: 0.4817

HELIX: 0.0174

FCONS_SCORE: 0.9334

RIG_SCORE: 0.7598

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1359M	TCGA-94-8491	LUSC	TCGA	EGEMKVPDV	DEG_COP1_1	0.2778
p.I1359M	DO219174	LUSC	ICGC	EGEMKVPDV	DEG_COP1_1	0.2778
p.K1363R	TCGA-A1-A0SK	BRCA	TCGA	EGEMKVPDV	DEG_COP1_1	0.6111
p.K1363R	DO4143	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.6111
p.D1340H	TCGA-A2-A0YK	BRCA	TCGA	EGEMKVPDV	DEG_COP1_1	0.0833
p.D1340H	DO2836	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.0833
p.D1342Y	TCGA-CV-7248	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	0.1389
p.D1342Y	DO14806	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	0.1389
p.L1345F	TCGA-UF-A7JT	HNSC	TCGA	EGEMKVPDV	DEG_COP1_1	0.2222
p.L1345F	DO219090	HNSC	ICGC	EGEMKVPDV	DEG_COP1_1	0.2222
p.S1344F	DO220893	MELA	ICGC	EGEMKVPDV	DEG_COP1_1	0.6389
p.D1340V	SIDM00481	Ovarian Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.0833
p.D1340V	ACH-000116	Ovarian Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.0833
p.D1340V	OAW-28	ovary	COSMIC	EGEMKVPDV	DEG_COP1_1	0.0833
p.I1359S	SIDM01588	Endometrial Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.2778
p.I1359S	ACH-000993	Endometrial/Uterine Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1221:1229	EGEMKVPDV	COP1	0.9542	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1349:1357	EGEMKVPDV	COP1	0.9174	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1679:1687	EGEMKVPDV	COP1	0.8823	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2015:2023	EGEMKVPDV	COP1	0.8467	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2210:2218	EGEMKVPDV	COP1	0.8923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons