DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 2015:2023

E3 ligase: COP1

DEGRON score: 0.8467

ASA_SCORE: 74.1667

COIL: 0.4022

CONS_SCORE: 0.432

DSS_SCORE: 0.5117

HELIX: 0.0142

FCONS_SCORE: 1.0049

RIG_SCORE: 0.7541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K2013N	TCGA-55-6969	LUAD	TCGA	EGEMKVPDV	DEG_COP1_1	0.2778
p.K2013N	DO24586	LUAD	ICGC	EGEMKVPDV	DEG_COP1_1	0.2778
p.D2022Y	TCGA-EO-A22R	UCEC	TCGA	EGEMKVPDV	DEG_COP1_1	0.7325
p.D2022Y	DO42713	UCEC	ICGC	EGEMKVPDV	DEG_COP1_1	0.7325
p.P2028L	TCGA-IB-7651	PAAD	TCGA	EGEMKVPDV	DEG_COP1_1	0.1944
p.P2028L	DO46657	PAAD	ICGC	EGEMKVPDV	DEG_COP1_1	0.1944
p.I2025M	TCGA-XF-A8HE	BLCA	TCGA	EGEMKVPDV	DEG_COP1_1	0.2778
p.I2025M	DO49797	BLCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.2778
p.E2015Q	DO224700	BRCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.6744
p.V2023A	DO52450	COCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.5825
p.G2005E	DO50970	LICA	ICGC	EGEMKVPDV	DEG_COP1_1	0.0556
p.M2018I	DO222363	MELA	ICGC	EGEMKVPDV	DEG_COP1_1	0.6507
p.M2030I	DO218872	SKCA	ICGC	EGEMKVPDV	DEG_COP1_1	0.1389
p.G2027V	SIDM00965	Small Cell Lung Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.2222
p.G2027V	ACH-000800	Lung Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.2222
p.G2027V	NCI-H446	lung	COSMIC	EGEMKVPDV	DEG_COP1_1	0.2222
p.E2015K	ACH-000868	Lung Cancer	CCLE	EGEMKVPDV	DEG_COP1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1221:1229	EGEMKVPDV	COP1	0.9542	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1349:1357	EGEMKVPDV	COP1	0.9174	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1679:1687	EGEMKVPDV	COP1	0.8823	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2015:2023	EGEMKVPDV	COP1	0.8467	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2210:2218	EGEMKVPDV	COP1	0.8923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons