DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 2210:2218

E3 ligase: COP1

DEGRON score: 0.8923

ASA_SCORE: 77.5111

COIL: 0.4201

CONS_SCORE: 0.2577

DSS_SCORE: 0.4933

HELIX: 0.0112

FCONS_SCORE: 1.0693

RIG_SCORE: 0.7577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2223L	TCGA-A5-A0G2	UCEC	TCGA	EGEMKVPDV	DEG_COP1_1	0.1944
p.P2223L	DO41235	UCEC	ICGC	EGEMKVPDV	DEG_COP1_1	0.1944
p.D2203Y	DO52694	MALY	ICGC	EGEMKVPDV	DEG_COP1_1	0.1389
p.G2222W	SIDM00945	Colorectal Carcinoma	GDSC	EGEMKVPDV	DEG_COP1_1	0.2222
p.G2222W	CL-34	large_intestine	COSMIC	EGEMKVPDV	DEG_COP1_1	0.2222
p.E2210K	Sarc9371	bone	COSMIC	EGEMKVPDV	DEG_COP1_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1221:1229	EGEMKVPDV	COP1	0.9542	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1349:1357	EGEMKVPDV	COP1	0.9174	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	1679:1687	EGEMKVPDV	COP1	0.8823	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2015:2023	EGEMKVPDV	COP1	0.8467	More...
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2210:2218	EGEMKVPDV	COP1	0.8923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons