DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: LIG_APCC_ABBA_1

Location: 4954:4959

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9634

ASA_SCORE: 70.4667

COIL: 0.5985

CONS_SCORE: 0.4956

DSS_SCORE: 0.5528

HELIX: 0.0348

FCONS_SCORE: 0.9101

RIG_SCORE: 0.7324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D4962Y	TCGA-2W-A8YY	CESC	TCGA	LDVHMD	LIG_APCC_ABBA_1	0.25
p.D4962Y	DO223732	CESC	ICGC	LDVHMD	LIG_APCC_ABBA_1	0.25
p.E4950Q	TCGA-B5-A11R	UCEC	TCGA	LDVHMD	LIG_APCC_ABBA_1	0.2222
p.E4950Q	DO43787	UCEC	ICGC	LDVHMD	LIG_APCC_ABBA_1	0.2222
p.D4959G	TCGA-CA-6717	COAD	TCGA	LDVHMD	LIG_APCC_ABBA_1	0.7198
p.D4959G	DO8264	COAD	ICGC	LDVHMD	LIG_APCC_ABBA_1	0.7198
p.I4963V	TCGA-IQ-A6SG	HNSC	TCGA	LDVHMD	LIG_APCC_ABBA_1	0.2222
p.I4963V	DO223267	HNSC	ICGC	LDVHMD	LIG_APCC_ABBA_1	0.2222
p.M4958T	DO227844	COCA	ICGC	LDVHMD	LIG_APCC_ABBA_1	0.6312
p.M4958T	DO233624	GACA	ICGC	LDVHMD	LIG_APCC_ABBA_1	0.6312
p.E4966K	SIDM00820	Kidney Carcinoma	GDSC	LDVHMD	LIG_APCC_ABBA_1	0.1389
p.E4966K	ACH-002188	Kidney Cancer	CCLE	LDVHMD	LIG_APCC_ABBA_1	0.1389
p.E4966K	RCC-ER	kidney	COSMIC	LDVHMD	LIG_APCC_ABBA_1	0.1389
p.E4966D	ACH-000975	Lung Cancer	CCLE	LDVHMD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	LIG_APCC_ABBA_1	4954:4959	LDVHMD	APC,CDC20,FZR1	0.9634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons