DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_SCF_FBW7_1

Location: 5792:5798

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 68.4571

COIL: 0.86

CONS_SCORE: 0.4152

DSS_SCORE: 0.6222

HELIX: 0.0221

FCONS_SCORE: 1.0699

RIG_SCORE: 0.6044

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T5796M	TCGA-55-A490	LUAD	TCGA	PSTPTGT	DEG_SCF_FBW7_1	0.7423
p.T5796M	DO24596	LUAD	ICGC	PSTPTGT	DEG_SCF_FBW7_1	0.7423
p.T5796M	SIDM00444	Esophageal Carcinoma	GDSC	PSTPTGT	DEG_SCF_FBW7_1	0.7423
p.T5798M	TCGA-AP-A1DK	UCEC	TCGA	PSTPTGT	DEG_SCF_FBW7_1	0.8534
p.T5798M	DO8858	COAD	ICGC	PSTPTGT	DEG_SCF_FBW7_1	0.8534
p.T5798M	DO42033	UCEC	ICGC	PSTPTGT	DEG_SCF_FBW7_1	0.8534
p.S5782L	TCGA-EE-A29E	SKCM	TCGA	PSTPTGT	DEG_SCF_FBW7_1	0.5
p.S5782L	DO37831	SKCM	ICGC	PSTPTGT	DEG_SCF_FBW7_1	0.5
p.G5804W	TCGA-XF-A9T8	BLCA	TCGA	PSTPTGT	DEG_SCF_FBW7_1	0.1667
p.G5804W	DO51927	BLCA	ICGC	PSTPTGT	DEG_SCF_FBW7_1	0.1667
p.G5803D	SIDM01739	Small Cell Lung Carcinoma	GDSC	PSTPTGT	DEG_SCF_FBW7_1	0.1944
p.S5807F	SIDM01689	B-Lymphoblastic Leukemia	GDSC	PSTPTGT	DEG_SCF_FBW7_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_SCF_FBW7_1	5792:5798	PSTPTGT	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons