DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_SCF_FBW7_1

Location: 692:698

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 80.3286

COIL: 0.7196

CONS_SCORE: 0.5248

DSS_SCORE: 0.46

HELIX: 0.02

FCONS_SCORE: 1.1738

RIG_SCORE: 0.7413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M699V	TCGA-06-5416	GBM	TCGA	VKTPKIS	DEG_SCF_FBW7_1	0.3056
p.M699V	DO10880	GBM	ICGC	VKTPKIS	DEG_SCF_FBW7_1	0.3056
p.D684N	TCGA-A5-A0G2	UCEC	TCGA	VKTPKIS	DEG_SCF_FBW7_1	0.1111
p.D684N	TCGA-AX-A0J0	UCEC	TCGA	VKTPKIS	DEG_SCF_FBW7_1	0.1111
p.D684N	TCGA-F5-6814	READ	TCGA	VKTPKIS	DEG_SCF_FBW7_1	0.1111
p.D684N	DO36556	READ	ICGC	VKTPKIS	DEG_SCF_FBW7_1	0.1111
p.D684N	DO41235	UCEC	ICGC	VKTPKIS	DEG_SCF_FBW7_1	0.1111
p.D684N	DO41133	UCEC	ICGC	VKTPKIS	DEG_SCF_FBW7_1	0.1111
p.D703Y	TCGA-B5-A1MR	UCEC	TCGA	VKTPKIS	DEG_SCF_FBW7_1	0.1944
p.D703Y	DO41758	UCEC	ICGC	VKTPKIS	DEG_SCF_FBW7_1	0.1944
p.I697F	TCGA-W5-AA39	CHOL	TCGA	VKTPKIS	DEG_SCF_FBW7_1	0.6304

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_SCF_FBW7_1	692:698	VKTPKIS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons