DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 2150:2158

E3 ligase: COP1

DEGRON score: 0.7529

ASA_SCORE: 65.6889

COIL: 0.4957

CONS_SCORE: 0.549

DSS_SCORE: 0.4741

HELIX: 0.0243

FCONS_SCORE: 1.1186

RIG_SCORE: 0.7723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2165V	TCGA-83-5908	LUAD	TCGA	SVDVEVPDV	DEG_COP1_1	0.1389
p.A2165V	DO23572	LUAD	ICGC	SVDVEVPDV	DEG_COP1_1	0.1389
p.D2164H	TCGA-AC-A23H	BRCA	TCGA	SVDVEVPDV	DEG_COP1_1	0.1667
p.D2164H	DO2401	BRCA	ICGC	SVDVEVPDV	DEG_COP1_1	0.1667
p.D2145E	TCGA-AG-3892	READ	TCGA	SVDVEVPDV	DEG_COP1_1	0.1944
p.D2145E	DO36394	READ	ICGC	SVDVEVPDV	DEG_COP1_1	0.1944
p.P2149H	TCGA-D5-6928	COAD	TCGA	SVDVEVPDV	DEG_COP1_1	0.3056
p.P2149H	DO7776	COAD	ICGC	SVDVEVPDV	DEG_COP1_1	0.3056
p.S2150I	TCGA-EM-A4FQ	THCA	TCGA	SVDVEVPDV	DEG_COP1_1	0.8453
p.S2150I	DO48119	THCA	ICGC	SVDVEVPDV	DEG_COP1_1	0.8453
p.K2141T	DO222884	COCA	ICGC	SVDVEVPDV	DEG_COP1_1	0.1944
p.P2156T	DO229026	LICA	ICGC	SVDVEVPDV	DEG_COP1_1	0.7031
p.D2164V	SIDM00594	Acute Myeloid Leukemia	GDSC	SVDVEVPDV	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2150:2158	SVDVEVPDV	COP1	0.7529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons