DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 4995:5003

E3 ligase: COP1

DEGRON score: 0.9657

ASA_SCORE: 68.6444

COIL: 0.5949

CONS_SCORE: 0.5265

DSS_SCORE: 0.4288

HELIX: 0.0569

FCONS_SCORE: 1.0047

RIG_SCORE: 0.7648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V5000L	TCGA-06-5856	GBM	TCGA	SLDVTVPEA	DEG_COP1_1	0.6765
p.V5000L	DO13456	GBM	ICGC	SLDVTVPEA	DEG_COP1_1	0.6765
p.N5006D	TCGA-AP-A1DK	UCEC	TCGA	SLDVTVPEA	DEG_COP1_1	0.25
p.N5006D	DO42033	UCEC	ICGC	SLDVTVPEA	DEG_COP1_1	0.25
p.A4989G	TCGA-BA-4077	HNSC	TCGA	SLDVTVPEA	DEG_COP1_1	0.1667
p.A4989G	DO15647	HNSC	ICGC	SLDVTVPEA	DEG_COP1_1	0.1667
p.E5002K	TCGA-XF-A9T8	BLCA	TCGA	SLDVTVPEA	DEG_COP1_1	0.7022
p.E5002K	DO51927	BLCA	ICGC	SLDVTVPEA	DEG_COP1_1	0.7022
p.P5001L	SIDM00006	Other Solid Cancers	GDSC	SLDVTVPEA	DEG_COP1_1	0.7582
p.P5001L	ACH-001552	Skin Cancer	CCLE	SLDVTVPEA	DEG_COP1_1	0.7582
p.P5001L	MCC26	skin	COSMIC	SLDVTVPEA	DEG_COP1_1	0.7582
p.P5001S	SIDM00006	Other Solid Cancers	GDSC	SLDVTVPEA	DEG_COP1_1	0.6752
p.P5001S	ACH-001552	Skin Cancer	CCLE	SLDVTVPEA	DEG_COP1_1	0.6752
p.P5001S	MCC26	skin	COSMIC	SLDVTVPEA	DEG_COP1_1	0.6752
p.V4998A	SIDM00217	Colorectal Carcinoma	GDSC	SLDVTVPEA	DEG_COP1_1	0.5825
p.V4998A	ACH-000999	Colon/Colorectal Cancer	CCLE	SLDVTVPEA	DEG_COP1_1	0.5825
p.V4998A	SNU-1040	large_intestine	COSMIC	SLDVTVPEA	DEG_COP1_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	4995:5003	SLDVTVPEA	COP1	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons