DegronMD

Uniprot ID: Q09666

Source protein: Neuroblast differentiation-associated protein AHNAK

Source gene: AHNAK

Class: DEG_COP1_1

Location: 2470:2478

E3 ligase: COP1

DEGRON score: 0.8979

ASA_SCORE: 66.3667

COIL: 0.509

CONS_SCORE: 0.4383

DSS_SCORE: 0.4544

HELIX: 0.0136

FCONS_SCORE: 1.1827

RIG_SCORE: 0.7616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M2487I	TCGA-CV-7427	HNSC	TCGA	DVDVSVPEV	DEG_COP1_1	0.0833
p.M2487I	TCGA-DK-A3WW	BLCA	TCGA	DVDVSVPEV	DEG_COP1_1	0.0833
p.M2487I	DO481	BLCA	ICGC	DVDVSVPEV	DEG_COP1_1	0.0833
p.M2487I	DO14286	HNSC	ICGC	DVDVSVPEV	DEG_COP1_1	0.0833
p.N2461K	ACH-001970	Metastasis	CCLE	DVDVSVPEV	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09666	Neuroblast differentiation-associated protein AHNAK	DEG_COP1_1	2470:2478	DVDVSVPEV	COP1	0.8979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons