DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EGDMQVPDL
Uniprot ID:
Q09666
Source protein:
Neuroblast differentiation-associated protein AHNAK
Source gene:
AHNAK
Class:
DEG_COP1_1
Location:
3899:3907
E3 ligase:
COP1
DEGRON score:
0.9003
ASA_SCORE:
77.1222
COIL:
0.5521
CONS_SCORE:
0.3593
DSS_SCORE:
0.5069
HELIX:
0.0246
FCONS_SCORE:
0.9798
RIG_SCORE:
0.7558
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L3907V
TCGA-34-8454
LUSC
TCGA
EGDMQVPDL
DEG_COP1_1
0.5654
p.L3907V
DO50094
LUSC
ICGC
EGDMQVPDL
DEG_COP1_1
0.5654
p.L3907V
SIDM00210
Ovarian Carcinoma
GDSC
EGDMQVPDL
DEG_COP1_1
0.5654
p.L3907V
SIDM01147
Gastric Carcinoma
GDSC
EGDMQVPDL
DEG_COP1_1
0.5654
p.V3898G
TCGA-AP-A1DV
UCEC
TCGA
EGDMQVPDL
DEG_COP1_1
0.3056
p.V3898G
DO43186
UCEC
ICGC
EGDMQVPDL
DEG_COP1_1
0.3056
p.D3892N
TCGA-LN-A49S
ESCA
TCGA
EGDMQVPDL
DEG_COP1_1
0.1389
p.M3891V
DO222737
COCA
ICGC
EGDMQVPDL
DEG_COP1_1
0.1111
p.L3895M
DO229038
LICA
ICGC
EGDMQVPDL
DEG_COP1_1
0.2222
p.D3890G
DO23516
LIRI
ICGC
EGDMQVPDL
DEG_COP1_1
0.0833
Drug responses associated with AHNAK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EGDMQVPDL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q09666
Neuroblast differentiation-associated protein AHNAK
DEG_COP1_1
3899:3907
EGDMQVPDL
COP1
0.9003
More...